N-{4-[(carbamothioylamino)methyl]benzyl}-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Base Information

Chemical Name:N-{4-[(carbamothioylamino)methyl]benzyl}-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide
CAS No.:1456890-51-9
Molecular Formula:C₁₆H₁₅N₅O₂S₂
Molecular Weight:373.459
Hs Code.:

Synonyms:N-{4-[(carbamothioylamino)methyl]benzyl}-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

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Chemical Property of N-{4-[(carbamothioylamino)methyl]benzyl}-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

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Technology Process of N-{4-[(carbamothioylamino)methyl]benzyl}-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

There total 5 articles about N-{4-[(carbamothioylamino)methyl]benzyl}-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1456890-50-8
N-(4-{[(benzoylcarbamothioyl)amino]methyl}benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

: 1456890-51-9
N-{4-[(carbamothioylamino)methyl]benzyl}-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jm400718n

Reference yield:

: 844502-63-2
3-ethyl 4-methyl 2-aminothiophene-3,4-dicarboxylate

: 1456890-51-9
N-{4-[(carbamothioylamino)methyl]benzyl}-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 70 h / Inert atmosphere; Reflux

2: ethanol / 18 h / 80 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 60 °C / Inert atmosphere

4: acetonitrile / 14 h / 0 - 20 °C / Inert atmosphere

5: potassium carbonate / methanol / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; methanol; ethanol; acetonitrile;
DOI:10.1021/jm400718n

Reference yield:

: 1456890-43-9
tert-butyl 4-[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamido)methyl]benzylcarbamate

: 1456890-51-9
N-{4-[(carbamothioylamino)methyl]benzyl}-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 60 °C / Inert atmosphere

2: acetonitrile / 14 h / 0 - 20 °C / Inert atmosphere

3: potassium carbonate / methanol / 12 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; methanol; acetonitrile;
DOI:10.1021/jm400718n