methyl N-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl) benzyl]carbamimidothioate

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Chemical Name:methyl N-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl) benzyl]carbamimidothioate
CAS No.:1456890-52-0
Molecular Formula:C₁₇H₁₇N₅O₂S₂
Molecular Weight:387.486
Hs Code.:

Synonyms:methyl N-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl) benzyl]carbamimidothioate

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Chemical Property of methyl N-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl) benzyl]carbamimidothioate

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Technology Process of methyl N-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl) benzyl]carbamimidothioate

There total 6 articles about methyl N-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl) benzyl]carbamimidothioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1456890-51-9
N-{4-[(carbamothioylamino)methyl]benzyl}-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

: 74-88-4
methyl iodide

: 1456890-52-0
methyl N-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl) benzyl]carbamimidothioate

Guidance literature:: In N,N-dimethyl-formamide; at 50 ℃; Inert atmosphere; Sealed tube;
DOI:10.1021/jm400718n

Reference yield:

: 844502-63-2
3-ethyl 4-methyl 2-aminothiophene-3,4-dicarboxylate

: 1456890-52-0
methyl N-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl) benzyl]carbamimidothioate

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 70 h / Inert atmosphere; Reflux

2: ethanol / 18 h / 80 °C / Inert atmosphere

3: hydrogenchloride / 1,4-dioxane; methanol / 1 h / 60 °C / Inert atmosphere

4: acetonitrile / 14 h / 0 - 20 °C / Inert atmosphere

5: potassium carbonate / methanol / 12 h / 20 °C / Inert atmosphere

6: N,N-dimethyl-formamide / 50 °C / Inert atmosphere; Sealed tube

With hydrogenchloride; potassium carbonate; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm400718n

Reference yield:

: 1456890-50-8
N-(4-{[(benzoylcarbamothioyl)amino]methyl}benzyl)-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-5-carboxamide

: 1456890-52-0
methyl N-[4-({[(4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-5-yl)carbonyl]amino}methyl) benzyl]carbamimidothioate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / methanol / 12 h / 20 °C / Inert atmosphere

2: N,N-dimethyl-formamide / 50 °C / Inert atmosphere; Sealed tube

With potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm400718n