o-(benzyloxy)valerophenone

Base Information

• Chemical Name: o-(benzyloxy)valerophenone
• CAS No.: 127154-56-7
• Molecular Formula: C₁₈H₂₀O₂
• Molecular Weight: 268.356
• Mol file: 127154-56-7.mol

Synonyms:o-(benzyloxy)valerophenone

Chemical Property of o-(benzyloxy)valerophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of o-(benzyloxy)valerophenone

There total 2 articles about o-(benzyloxy)valerophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

Potassium; 2-pentanoyl-phenolate + benzyl chloride (100-44-7) → o-(benzyloxy)valerophenone (127154-56-7)

Guidance literature:

In methanol; for 2h; Heating;

DOI:10.1021/ja00169a031

Reference yield:

2-benzyloxybenzoyl chloride (4349-62-6) → o-(benzyloxy)valerophenone (127154-56-7)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 1 h / 0 - 20 °C

2: toluene / 2 h / -78 °C

In toluene;

DOI:10.1021/acs.joc.1c03160

Reference yield:

o-(benzyloxy)valerophenone (127154-56-7) → 2'-benzyloxyacetophenone (31165-67-0)

Guidance literature:

In benzene; Quantum yield; Thermodynamic data; Irradiation; other solvent; E_a, log A;

DOI:10.1021/ja00169a031

upstream raw materials:

benzyl chloride

2-benzyloxybenzoyl chloride

Downstream raw materials:

2'-benzyloxyacetophenone