(±)-1-(7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)-2-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)ethanol

Base Information

Chemical Name:(±)-1-(7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)-2-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)ethanol
CAS No.:1458062-05-9
Molecular Formula:C₂₉H₃₉N₅O₂Si
Molecular Weight:517.746
Hs Code.:

Synonyms:(±)-1-(7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)-2-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)ethanol

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Chemical Property of (±)-1-(7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)-2-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)ethanol

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Technology Process of (±)-1-(7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)-2-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)ethanol

There total 9 articles about (±)-1-(7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)-2-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-(((1H-imidazol-4-yl)methyl)(benzyl)amino)ethanol

: 1458062-05-9
(±)-1-(7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)-2-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)ethanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / dichloromethane / 40 °C

2.1: triethylamine / acetonitrile / 82 °C

3.1: n-butyllithium / tetrahydrofuran / -78 - 0 °C

3.2: -78 °C

4.1: isopropyl alcohol

5.1: caesium carbonate / tetrahydrofuran; isopropyl alcohol

6.1: sodium tetrahydroborate / ethanol

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; caesium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; acetonitrile; 5.1: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmcl.2013.08.031

Reference yield:

: 1458062-03-7
(±)-diphenyl (7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)(phenylamino)methylphosphonate

: 1458062-05-9
(±)-1-(7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)-2-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / tetrahydrofuran; isopropyl alcohol

2: sodium tetrahydroborate / ethanol

With sodium tetrahydroborate; caesium carbonate; In tetrahydrofuran; ethanol; isopropyl alcohol; 1: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmcl.2013.08.031

Reference yield:

: 104-63-2
N-Benzylethanolamine

: 1458062-05-9
(±)-1-(7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)-2-(7-methyl-2-((2-(trimethylsilyl)ethoxy)methyl)-2H-indazol-5-yl)ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium tris(acetoxy)borohydride / tetrahydrofuran

2.1: thionyl chloride / dichloromethane / 40 °C

3.1: triethylamine / acetonitrile / 82 °C

4.1: n-butyllithium / tetrahydrofuran / -78 - 0 °C

4.2: -78 °C

5.1: isopropyl alcohol

6.1: caesium carbonate / tetrahydrofuran; isopropyl alcohol

7.1: sodium tetrahydroborate / ethanol

With sodium tetrahydroborate; n-butyllithium; thionyl chloride; sodium tris(acetoxy)borohydride; caesium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; acetonitrile; 6.1: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1016/j.bmcl.2013.08.031