(±)-diphenyl (7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)(phenylamino)methylphosphonate

Base Information

Chemical Name:(±)-diphenyl (7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)(phenylamino)methylphosphonate
CAS No.:1458062-03-7
Molecular Formula:C₃₂H₃₁N₄O₃P
Molecular Weight:550.597
Hs Code.:

Synonyms:(±)-diphenyl (7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)(phenylamino)methylphosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (±)-diphenyl (7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)(phenylamino)methylphosphonate

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Technology Process of (±)-diphenyl (7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)(phenylamino)methylphosphonate

There total 8 articles about (±)-diphenyl (7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)(phenylamino)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 4712-55-4
diphenyl hydrogen phosphite

: 7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazine-3-carbaldehyde

: 62-53-3
aniline

: 1458062-03-7
(±)-diphenyl (7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)(phenylamino)methylphosphonate

Guidance literature:: In isopropyl alcohol;

Reference yield: 85.0%

: 4712-55-4
diphenyl hydrogen phosphite

: 165894-25-7
C₁₄H₁₅N₃O

: 62-53-3
aniline

: 1458062-03-7
(±)-diphenyl (7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)(phenylamino)methylphosphonate

Guidance literature:: In isopropyl alcohol;
DOI:10.1016/j.bmcl.2013.08.031

Reference yield:

: 2-(((1H-imidazol-4-yl)methyl)(benzyl)amino)ethanol

: 1458062-03-7
(±)-diphenyl (7-benzyl-5,6,7,8-tetrahydroimidazo[1,5-a]pyrazin-3-yl)(phenylamino)methylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / dichloromethane / 40 °C

2.1: triethylamine / acetonitrile / 82 °C

3.1: n-butyllithium / tetrahydrofuran / -78 - 0 °C

3.2: -78 °C

4.1: isopropyl alcohol

With n-butyllithium; thionyl chloride; triethylamine; In tetrahydrofuran; dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.bmcl.2013.08.031