4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyric acid

Base Information

Chemical Name:4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyric acid
CAS No.:190276-53-0
Molecular Formula:C₃₂H₃₀N₂O₅S
Molecular Weight:554.667
Hs Code.:

Synonyms:4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyric acid

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Chemical Property of 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyric acid

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Technology Process of 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyric acid

There total 8 articles about 4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5081-36-7
3-methoxy-4-nitrobenzoic acid

: 190276-53-0
4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyric acid

Guidance literature:: Multi-step reaction with 7 steps

1: thionyl chloride / CHCl₃ / Heating

2: Et₃N / CHCl₃ / 20 °C

3: H₂ / Pd/C

4: Et₃N / 20 °C

5: BBr₃

6: 73.8 percent / K₂CO₃; KI / acetone / 12 h / Heating

7: 78.6 percent / KOH / methanol / 2 h / Heating

With potassium hydroxide; thionyl chloride; hydrogen; boron tribromide; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In methanol; chloroform; acetone;
DOI:10.1021/jm030287l

Reference yield:

: 67579-92-4
3-methoxy-4-nitrobenzoic acid chloride

: 190276-53-0
4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyric acid

Guidance literature:: Multi-step reaction with 6 steps

1: Et₃N / CHCl₃ / 20 °C

2: H₂ / Pd/C

3: Et₃N / 20 °C

4: BBr₃

5: 73.8 percent / K₂CO₃; KI / acetone / 12 h / Heating

6: 78.6 percent / KOH / methanol / 2 h / Heating

With potassium hydroxide; hydrogen; boron tribromide; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In methanol; chloroform; acetone;
DOI:10.1021/jm030287l

Reference yield:

: 190276-75-6
(3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone

: 190276-53-0
4-[2-[[[1,1'-biphenyl]-2-carbonyl]amino]-5-[(5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepin-4-yl)carbonyl]phenoxy]butyric acid

Guidance literature:: Multi-step reaction with 5 steps

1: H₂ / Pd/C

2: Et₃N / 20 °C

3: BBr₃

4: 73.8 percent / K₂CO₃; KI / acetone / 12 h / Heating

5: 78.6 percent / KOH / methanol / 2 h / Heating

With potassium hydroxide; hydrogen; boron tribromide; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In methanol; acetone;
DOI:10.1021/jm030287l