(3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone

Base Information

Chemical Name:(3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone
CAS No.:190276-75-6
Molecular Formula:C₁₆H₁₆N₂O₄S
Molecular Weight:332.38
Hs Code.:

Synonyms:(3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone

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Chemical Property of (3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone

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Technology Process of (3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone

There total 11 articles about (3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 67579-92-4
3-methoxy-4-nitrobenzoic acid chloride

: 180340-57-2
5,6,7,8-tetra-hydro-4H-thieno[3,2-b]azepine

: 190276-75-6
(3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone

Guidance literature:: With triethylamine; In chloroform; for 12h; Ambient temperature;
DOI:10.3987/COM-98-8104

Reference yield:

: 5081-36-7
3-methoxy-4-nitrobenzoic acid

: 190276-75-6
(3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / CHCl₃ / Heating

2: Et₃N / CHCl₃ / 20 °C

With thionyl chloride; triethylamine; In chloroform;
DOI:10.1021/jm030287l

Reference yield:

: 13414-95-4
4-keto-4,5,6,7-tetrahydrothianaphthene

: 190276-75-6
(3-Methoxy-4-nitro-phenyl)-(5,6,7,8-tetrahydro-thieno[3,2-b]azepin-4-yl)-methanone

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / hydroxylammonium chloride, pyridine / 2 h / Ambient temperature

2: 30 percent / phosphorus pentoxide, methanesulfonic acid / 5 h / 100 - 110 °C

3: 76 percent / sodium bis(2-methoxyethoxy)aluminum hydride / toluene / 1 h, r.t. then 1 h, 60 deg C

4: 92 percent / triethylamine / CHCl₃ / 12 h / Ambient temperature

With pyridine; phosphorus pentaoxide; methanesulfonic acid; hydroxylamine hydrochloride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; In chloroform; toluene;
DOI:10.3987/COM-98-8104