C₆₆H₇₇ClFN₉O₂₁

Base Information

Chemical Name:C₆₆H₇₇ClFN₉O₂₁
CAS No.:223572-37-0
Molecular Formula:C₆₆H₇₇ClFN₉O₂₁
Molecular Weight:1386.84
Hs Code.:

C<sub>66</sub>H<sub>77</sub>ClFN<sub>9</sub>O<sub>21</sub>

Synonyms:C₆₆H₇₇ClFN₉O₂₁

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₆₆H₇₇ClFN₉O₂₁

Chemical Property:

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Technology Process of C₆₆H₇₇ClFN₉O₂₁

There total 13 articles about C₆₆H₇₇ClFN₉O₂₁ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 207390-83-8
(S)-2-[(2R,3R)-2-[(R)-2-(tert-Butoxycarbonyl-methyl-amino)-4-methyl-pentanoylamino]-3-(4-fluoro-3-nitro-phenyl)-3-hydroxy-propionylamino]-3-cyano-propionic acid

: 223572-36-9
C₄₁H₄₅ClN₄O₁₃

: 223572-37-0
C₆₆H₇₇ClFN₉O₂₁

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 ℃; for 0.5h;
DOI:10.1021/ja992577q

Reference yield:

: 223572-32-5
C₂₂H₃₀BNO₉

: 223572-37-0
C₆₆H₇₇ClFN₉O₂₁

Guidance literature:: Multi-step reaction with 7 steps

1: Pd₂(dba)3; (o-tolyl)3P; 1 N aq. Na₂CO₃ / methanol; toluene / 0.25 h / 80 °C

2: 96 percent / Bu₄NF; AcOH / tetrahydrofuran / 6 h / 25 °C

3: 99 percent / 0.2 N aq. LiOH / tetrahydrofuran / 1 h / 0 °C

4: 80 percent / H₂ / 10 percent Pd/C / ethanol; ethyl acetate / 11 h / 25 °C

5: 63 percent / FDPP; DMAP / dimethylformamide / 25 °C

6: 95 percent / HCO₂H / CHCl₃ / 7 h / 25 °C

7: 63 percent / HOAt; EDCI / tetrahydrofuran / 0.5 h / 0 °C

With dmap; lithium hydroxide; formic acid; 1-hydroxy-7-aza-benzotriazole; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; pentafluorophenyl diphenyl-phosphinate; tetrabutyl ammonium fluoride; hydrogen; sodium carbonate; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; tris-(o-tolyl)phosphine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene; 1: Suzuki coupling / 2: desilylation / 3: Hydrolysis / 4: Hydrogenolysis / 5: Cyclization / 6: acidolysis / 7: Condensation;
DOI:10.1021/ja992577q

Reference yield:

: 223572-33-6
C₆₁H₇₇ClN₄O₁₈Si

: 223572-37-0
C₆₆H₇₇ClFN₉O₂₁

Guidance literature:: Multi-step reaction with 6 steps

1: 96 percent / Bu₄NF; AcOH / tetrahydrofuran / 6 h / 25 °C

2: 99 percent / 0.2 N aq. LiOH / tetrahydrofuran / 1 h / 0 °C

3: 80 percent / H₂ / 10 percent Pd/C / ethanol; ethyl acetate / 11 h / 25 °C

4: 63 percent / FDPP; DMAP / dimethylformamide / 25 °C

5: 95 percent / HCO₂H / CHCl₃ / 7 h / 25 °C

6: 63 percent / HOAt; EDCI / tetrahydrofuran / 0.5 h / 0 °C

With dmap; lithium hydroxide; formic acid; 1-hydroxy-7-aza-benzotriazole; pentafluorophenyl diphenyl-phosphinate; tetrabutyl ammonium fluoride; hydrogen; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; chloroform; ethyl acetate; N,N-dimethyl-formamide; 1: desilylation / 2: Hydrolysis / 3: Hydrogenolysis / 4: Cyclization / 5: acidolysis / 6: Condensation;
DOI:10.1021/ja992577q