4-nitrobenzyl 2-[(tert-butyldimethylsilyloxy)methyl]-4-(hydroxymethyl)phenylcarbamate

Base Information

• Chemical Name: 4-nitrobenzyl 2-[(tert-butyldimethylsilyloxy)methyl]-4-(hydroxymethyl)phenylcarbamate
• CAS No.: 1009314-98-0
• Molecular Formula: C₂₂H₃₀N₂O₆Si
• Molecular Weight: 446.575
• Mol file: 1009314-98-0.mol

Synonyms:4-nitrobenzyl 2-[(tert-butyldimethylsilyloxy)methyl]-4-(hydroxymethyl)phenylcarbamate

Chemical Property of 4-nitrobenzyl 2-[(tert-butyldimethylsilyloxy)methyl]-4-(hydroxymethyl)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-nitrobenzyl 2-[(tert-butyldimethylsilyloxy)methyl]-4-(hydroxymethyl)phenylcarbamate

There total 1 articles about 4-nitrobenzyl 2-[(tert-butyldimethylsilyloxy)methyl]-4-(hydroxymethyl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

2-[(tert-butyldimethylsilyloxy)methyl]-4-(hydroxymethyl)aniline (1009314-94-6) + 4-nitrophenyl (4-nitrophenyl)methyl carbonate (158556-65-1) → 4-nitrobenzyl 2-[(tert-butyldimethylsilyloxy)methyl]-4-(hydroxymethyl)phenylcarbamate (1009314-98-0)

Guidance literature:

With 4 A molecular sieve; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 16h;

DOI:10.1021/jo702484z

Reference yield: 96.0%

4-nitrobenzyl 2-[(tert-butyldimethylsilyloxy)methyl]-4-(hydroxymethyl)phenylcarbamate (1009314-98-0) + 4-Nitrophenyl chloroformate (7693-46-1) → 4-nitrobenzyl (2-[(tert-butyldimethylsilyloxy)methyl]-4-{[(4-nitrophenoxy)carbonyloxy]methyl}phenyl)carbamate (1009315-07-4)

Guidance literature:

With pyridine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jo702484z

Reference yield: 87.0%

4-nitrobenzyl 2-[(tert-butyldimethylsilyloxy)methyl]-4-(hydroxymethyl)phenylcarbamate (1009314-98-0) → 4-nitrobenzyl 2,4-bis(hydroxymethyl)phenylcarbamate (1009315-00-7)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; for 0.25h;

DOI:10.1021/jo702484z

upstream raw materials:

2-[(tert-butyldimethylsilyloxy)methyl]-4-(hydroxymethyl)aniline

4-nitrophenyl (4-nitrophenyl)methyl carbonate

Downstream raw materials:

4-nitrobenzyl 2,4-bis(hydroxymethyl)phenylcarbamate

4-nitrobenzyl (2-[(tert-butyldimethylsilyloxy)methyl]-4-{[(4-nitrophenoxy)carbonyloxy]methyl}phenyl)carbamate