4-(benzyloxycarbonylamino)-5-[2-benzoyl-5-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylamino]-5-oxopentanoic acid tert-butyl ester

Base Information

• Chemical Name: 4-(benzyloxycarbonylamino)-5-[2-benzoyl-5-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylamino]-5-oxopentanoic acid tert-butyl ester
• CAS No.: 1073843-74-9
• Molecular Formula: C₃₉H₄₈N₄O₈
• Molecular Weight: 700.832
• Mol file: 1073843-74-9.mol

Synonyms:4-(benzyloxycarbonylamino)-5-[2-benzoyl-5-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylamino]-5-oxopentanoic acid tert-butyl ester

Chemical Property of 4-(benzyloxycarbonylamino)-5-[2-benzoyl-5-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylamino]-5-oxopentanoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(benzyloxycarbonylamino)-5-[2-benzoyl-5-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylamino]-5-oxopentanoic acid tert-butyl ester

There total 1 articles about 4-(benzyloxycarbonylamino)-5-[2-benzoyl-5-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylamino]-5-oxopentanoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

[4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-aminophenyl]phenylmethanone (1073842-97-3) + 5-tert-butyl N-benzyloxycarbonyl-L-glutamate (3886-08-6) → 4-(benzyloxycarbonylamino)-5-[2-benzoyl-5-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylamino]-5-oxopentanoic acid tert-butyl ester (1073843-74-9)

Guidance literature:

5-tert-butyl N-benzyloxycarbonyl-L-glutamate; With 1,1,1,3,3,3-hexachloro-propan-2-one; triphenylphosphine; In dichloromethane; at -10 ℃; for 0.25h;

[4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-aminophenyl]phenylmethanone; In dichloromethane; at -10 - 23 ℃;

DOI:10.1021/jo8015456

Reference yield: 25.0%

4-(benzyloxycarbonylamino)-5-[2-benzoyl-5-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylamino]-5-oxopentanoic acid tert-butyl ester (1073843-74-9) → 3-(2-(tert-butoxycarbonyl)ethyl)-5-phenyl-8-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1,3-dihydrobenzo[e][1,4]diazepin-2-one (1073844-12-8)

Guidance literature:

With 10% Pd/C; cyclohexene; In ethanol; Reflux;

DOI:10.1021/jo8015456

upstream raw materials:

[4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-aminophenyl]phenylmethanone

5-tert-butyl N-benzyloxycarbonyl-L-glutamate

Downstream raw materials:

3-(2-(tert-butoxycarbonyl)ethyl)-5-phenyl-8-(4-(tert-butoxycarbonyl)piperazin-1-yl)-1,3-dihydrobenzo[e][1,4]diazepin-2-one