[4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-aminophenyl]phenylmethanone

Base Information

• Chemical Name: [4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-aminophenyl]phenylmethanone
• CAS No.: 1073842-97-3
• Molecular Formula: C₂₂H₂₇N₃O₃
• Molecular Weight: 381.475
• Mol file: 1073842-97-3.mol

Synonyms:[4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-aminophenyl]phenylmethanone

Chemical Property of [4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-aminophenyl]phenylmethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-aminophenyl]phenylmethanone

There total 2 articles about [4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-aminophenyl]phenylmethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

[4-(4-benzylpiperazin-1-yl)-2-aminophenyl]phenylmethanone (1073843-00-1) + di-tert-butyl dicarbonate (24424-99-5) → [4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-aminophenyl]phenylmethanone (1073842-97-3)

Guidance literature:

[4-(4-benzylpiperazin-1-yl)-2-aminophenyl]phenylmethanone; With 10% Pd/C; cyclohexene; In ethanol; for 16h; Reflux;

di-tert-butyl dicarbonate; In ethanol; for 3h; Reflux;

DOI:10.1021/jo8015456

Reference yield: 30.0%

(4-bromo-2-aminophenyl)phenyl-methanone (135776-98-6) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → [4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-aminophenyl]phenylmethanone (1073842-97-3)

Guidance literature:

at 130 ℃; for 48h;

DOI:10.1021/jo8015456

Reference yield: 89.0%

[4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-aminophenyl]phenylmethanone (1073842-97-3) + N-(Benzyloxycarbonyl)glycine (1138-80-3) → 2-(benzyloxycarbonylamino)-N-[2-benzoyl-5-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl]acetamide (1073843-11-4)

Guidance literature:

N-(Benzyloxycarbonyl)glycine; With 1,1,1,3,3,3-hexachloro-propan-2-one; triphenylphosphine; In dichloromethane; at -10 ℃; for 0.25h;

[4-(4-(tert-butoxycarbonyl)piperazin-1-yl)-2-aminophenyl]phenylmethanone; In dichloromethane; at -10 - 23 ℃;

DOI:10.1021/jo8015456

upstream raw materials:

[4-(4-benzylpiperazin-1-yl)-2-aminophenyl]phenylmethanone

di-tert-butyl dicarbonate

(4-bromo-2-aminophenyl)phenyl-methanone

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

2-(benzyloxycarbonylamino)-N-[2-benzoyl-5-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl]-3-phenylpropanamide

2-(benzyloxycarbonylamino)-N-[2-benzoyl-5-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl]-3-(benzyloxy)propanamide

4-(benzyloxycarbonylamino)-5-[2-benzoyl-5-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenylamino]-5-oxopentanoic acid tert-butyl ester

2-(benzyloxycarbonylamino)-N-[2-benzoyl-5-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl]-3-phenylpropanamide