4-(3-(3,4-dichlorophenyl)propylcarbamoyl)-1-methyl-2-oxo-1,2-dihydropyridin-3-yl trifluoromethane sulfonate

Base Information

Chemical Name:4-(3-(3,4-dichlorophenyl)propylcarbamoyl)-1-methyl-2-oxo-1,2-dihydropyridin-3-yl trifluoromethane sulfonate
CAS No.:1429204-86-3
Molecular Formula:C₁₇H₁₅Cl₂F₃N₂O₅S
Molecular Weight:487.284
Hs Code.:

Synonyms:4-(3-(3,4-dichlorophenyl)propylcarbamoyl)-1-methyl-2-oxo-1,2-dihydropyridin-3-yl trifluoromethane sulfonate

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Chemical Property of 4-(3-(3,4-dichlorophenyl)propylcarbamoyl)-1-methyl-2-oxo-1,2-dihydropyridin-3-yl trifluoromethane sulfonate

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Technology Process of 4-(3-(3,4-dichlorophenyl)propylcarbamoyl)-1-methyl-2-oxo-1,2-dihydropyridin-3-yl trifluoromethane sulfonate

There total 10 articles about 4-(3-(3,4-dichlorophenyl)propylcarbamoyl)-1-methyl-2-oxo-1,2-dihydropyridin-3-yl trifluoromethane sulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 1429203-35-9
N-(3-(3,4-dichlorophenyl)propyl)-3-hydroxy-1,6-dimethyl-2-oxo-1,2-dihydropyridine-4-carboxamide

: 1429204-86-3
4-(3-(3,4-dichlorophenyl)propylcarbamoyl)-1-methyl-2-oxo-1,2-dihydropyridin-3-yl trifluoromethane sulfonate

Guidance literature:: With pyridine; dmap; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 130879-43-5
3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid ethyl ester

: 1429204-86-3
4-(3-(3,4-dichlorophenyl)propylcarbamoyl)-1-methyl-2-oxo-1,2-dihydropyridin-3-yl trifluoromethane sulfonate

Guidance literature:: Multi-step reaction with 7 steps

1: N-Bromosuccinimide / 1,2-dichloro-ethane / 20 °C

2: lithium hydroxide / water; tetrahydrofuran / 50 °C

3: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

4: triethylamine / dichloromethane / 20 °C

5: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 2 h / 110 °C / Microwave irradiation; Sealed tube

6: boron tribromide / dichloromethane / 20 °C

7: pyridine; dmap / dichloromethane / 2 h / 20 °C

With pyridine; dmap; N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; boron tribromide; sodium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

: 1429204-40-9
ethyl 6-bromo-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate

: 1429204-86-3
4-(3-(3,4-dichlorophenyl)propylcarbamoyl)-1-methyl-2-oxo-1,2-dihydropyridin-3-yl trifluoromethane sulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: lithium hydroxide / water; tetrahydrofuran / 50 °C

2: oxalyl dichloride / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

3: triethylamine / dichloromethane / 20 °C

4: sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane / 2 h / 110 °C / Microwave irradiation; Sealed tube

5: boron tribromide / dichloromethane / 20 °C

6: pyridine; dmap / dichloromethane / 2 h / 20 °C

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxalyl dichloride; boron tribromide; sodium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide;