1-(4-Methoxyphenyl)piperazine hydrochloride

Base Information

• Chemical Name: 1-(4-Methoxyphenyl)piperazine hydrochloride
• CAS No.: 70849-64-8
• Molecular Formula: C₁₁H₁₆N₂O*2ClH
• Molecular Weight: 265.183
• European Community (EC) Number: 254-166-6,282-270-1
• UNII: ARJ7BR8SNG
• DSSTox Substance ID: DTXSID50480212
• NSC Number: 71661
• Mol file: 70849-64-8.mol

Synonyms:1-(4-methoxyphenyl)piperazine hydrochloride;84145-43-7;70849-64-8;Piperazine, 1-(4-methoxyphenyl)-, monohydrochloride;1-(4-methoxyphenyl)piperazine;hydrochloride;1-(para-methoxyphenyl)piperazine hydrochloride;NSC-71661;1-(4-Methoxyphenyl)piperazine-1,4-diylium dichloride;Piperazine, 1-(4-methoxyphenyl)-, hydrochloride;1-(4-Methoxyphenyl)piperazinium chloride;SCHEMBL1724680;DTXSID50480212;HFJDUYKRPHHPAX-UHFFFAOYSA-N;1-(4-methoxyphenyl)piperazine hcl;AMY32502;NSC71661;AKOS015897766;4-methoxyphenyl piperazine hydrochloride;AC-25795;AS-65778;CS-0456123;FT-0650001;FT-0650010;1-(4-Methoxy-phenyl)-piperazine;D97787;A837007;1-(4-METHOXYPHENYL)PIPERAZINE (HYDROCHLORIDE);5-(2,5-Dimethoxy-phenyl)-2H-pyrazole-3-carboxylicacid

Chemical Property of 1-(4-Methoxyphenyl)piperazine hydrochloride

Chemical Property:

• PSA: 24.50000
• LogP: 2.30060
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 228.1029409
• Heavy Atom Count: 15
• Complexity: 161

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)N2CCNCC2.Cl

Technology Process of 1-(4-Methoxyphenyl)piperazine hydrochloride

There total 5 articles about 1-(4-Methoxyphenyl)piperazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

N-(4-tert-butoxycarbonyl)-N'-(4-methoxyphenyl)piperazine → 1-(para-methoxyphenyl)piperazine hydrochloride (84145-43-7,70849-64-8)

Guidance literature:

With hydrogenchloride; In diethyl ether;

Reference yield: 80.0%

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + 4-methoxy-aniline (104-94-9) → 1-(para-methoxyphenyl)piperazine hydrochloride (84145-43-7,70849-64-8)

Guidance literature:

With 2-(2-methoxyethoxy)ethyl alcohol; at 150 ℃; for 12h;

DOI:10.1016/j.bmc.2016.09.005

Reference yield: 66.0%

bis-(2-chloroethyl)amine hydrochloride (821-48-7) + 4-methoxy-aniline (104-94-9) → 1-(4-methoxyphenyl)piperazine hydrochloride (70849-64-8)

Guidance literature:

In diethylene glycol dimethyl ether; at 150 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2020.112257

upstream raw materials:

bis-(2-chloroethyl)amine hydrochloride

4-methoxy-aniline

para-iodoanisole

Downstream raw materials:

(2-chlorophenyl)(4-(4-methoxyphenyl)piperazin-1-yl)methanone

(3-chlorophenyl)(4-(4-methoxyphenyl)piperazin-1-yl)methanone

(thiophen-2-yl) (4-(4-methoxyphenyl)piperazin-1-yl)methanone

1-isovaleryl-4-(4-methoxyphenyl)piperazine