(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-2,3,6-trimethyl-hept-5-enyl ester

Base Information

Chemical Name:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-2,3,6-trimethyl-hept-5-enyl ester
CAS No.:142746-32-5
Molecular Formula:C₂₀H₂₇F₃O₃
Molecular Weight:372.428
Hs Code.:

Synonyms:(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-2,3,6-trimethyl-hept-5-enyl ester

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Chemical Property of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-2,3,6-trimethyl-hept-5-enyl ester

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Technology Process of (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-2,3,6-trimethyl-hept-5-enyl ester

There total 12 articles about (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-2,3,6-trimethyl-hept-5-enyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 20445-31-2
R-(+)-α-trifluoromethyl-α-methoxy-phenylacetic acid

: 142795-58-2
(2R,3R)-2,3,6-trimethyl-5-hepten-1-ol

: 142746-32-5
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-2,3,6-trimethyl-hept-5-enyl ester

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 10h; Inert atmosphere;
DOI:10.1002/anie.201811330

Reference yield:

: 65284-00-6
(R)-3-methyl-γ-butyrolactone

: 142746-32-5
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-2,3,6-trimethyl-hept-5-enyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 1) LDA / 1) THF, -78 deg C, 1 h, 2) -78 deg C, 1 h

2: DIBAL / toluene / 0.5 h / -78 °C

3: 1.93 g / ZnCl₂, molecular sieves 3 Angstroem / dioxane / 0.75 h / 75 °C

4: pyridinium p-toluenesulfonate / CH₂Cl₂ / 0.67 h / Ambient temperature

5: Li, EtNH₂ / 24 h / 0 °C

6: 63 percent / pyridinium p-toluenesulfonate / ethanol / 1.33 h / 50 °C

7: pyridine

With pyridine; 3 A molecular sieve; pyridinium p-toluenesulfonate; lithium; diisobutylaluminium hydride; ethylamine; zinc(II) chloride; lithium diisopropyl amide; In 1,4-dioxane; ethanol; dichloromethane; toluene;

Reference yield:

: 142746-34-7,142746-35-8,142746-36-9,142746-37-0
(2RS,3R,4R)-4-methyl-3-(3-methyl-2-butenyl)tetrahydrofuran-2-ol

: 142746-32-5
(R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (2R,3R)-2,3,6-trimethyl-hept-5-enyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1.93 g / ZnCl₂, molecular sieves 3 Angstroem / dioxane / 0.75 h / 75 °C

2: pyridinium p-toluenesulfonate / CH₂Cl₂ / 0.67 h / Ambient temperature

3: Li, EtNH₂ / 24 h / 0 °C

4: 63 percent / pyridinium p-toluenesulfonate / ethanol / 1.33 h / 50 °C

5: pyridine

With pyridine; 3 A molecular sieve; pyridinium p-toluenesulfonate; lithium; ethylamine; zinc(II) chloride; In 1,4-dioxane; ethanol; dichloromethane;