N'-(3-chloropropanoyl)-4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)benzohydrazide

Base Information

Chemical Name:N'-(3-chloropropanoyl)-4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)benzohydrazide
CAS No.:1309588-13-3
Molecular Formula:C₂₄H₂₈ClN₅O₂S
Molecular Weight:486.038
Hs Code.:

Synonyms:N'-(3-chloropropanoyl)-4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)benzohydrazide

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Chemical Property of N'-(3-chloropropanoyl)-4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)benzohydrazide

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Technology Process of N'-(3-chloropropanoyl)-4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)benzohydrazide

There total 5 articles about N'-(3-chloropropanoyl)-4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)benzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1309588-08-6
4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)benzohydrazide

: 625-36-5
2-chloropropionyl chloride

: 1309588-13-3
N'-(3-chloropropanoyl)-4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)benzohydrazide

Guidance literature:: With triethylamine; In benzene; for 10h; Reflux;
DOI:10.1007/s00044-010-9389-z

Reference yield:

: 15687-27-1,58560-75-1
ibuprofen

: 1309588-13-3
N'-(3-chloropropanoyl)-4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)benzohydrazide

Guidance literature:: Multi-step reaction with 6 steps

1.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 5 °C

2.1: tetrahydrofuran / 12 h / Reflux

3.1: hydrogenchloride; potassium hydroxide / water / Reflux

4.1: ethanol / 4 h / Reflux

5.1: thionyl chloride / 4 h / Reflux

5.2: 6 h / Reflux

6.1: triethylamine / benzene / 10 h / Reflux

With hydrogenchloride; thionyl chloride; triethylamine; dicyclohexyl-carbodiimide; potassium hydroxide; In tetrahydrofuran; ethanol; water; benzene;
DOI:10.1007/s00044-010-9389-z

Reference yield:

: 1309588-05-3
4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)benzoic acid

: 1309588-13-3
N'-(3-chloropropanoyl)-4-(3-(1-(4-isobutylphenyl)ethyl)-5-thioxo-1H-1,2,4-triazol-4(5H)-yl)benzohydrazide

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 4 h / Reflux

1.2: 6 h / Reflux

2.1: triethylamine / benzene / 10 h / Reflux

With thionyl chloride; triethylamine; In benzene;
DOI:10.1007/s00044-010-9389-z