alpha-isopropyl-alpha-[3-[N-[3-(3-hydroxymethylphenoxy)propyl]-N-methylamino]propyl]-3,4,5-trimethoxyphenylacetonitrile

Base Information

• Chemical Name: alpha-isopropyl-alpha-[3-[N-[3-(3-hydroxymethylphenoxy)propyl]-N-methylamino]propyl]-3,4,5-trimethoxyphenylacetonitrile
• CAS No.: 103523-51-9
• Molecular Formula: C₂₈H₄₀N₂O₅
• Molecular Weight: 484.636

Synonyms:alpha-isopropyl-alpha-[3-[N-[3-(3-hydroxymethylphenoxy)propyl]-N-methylamino]propyl]-3,4,5-trimethoxyphenylacetonitrile

Chemical Property of alpha-isopropyl-alpha-[3-[N-[3-(3-hydroxymethylphenoxy)propyl]-N-methylamino]propyl]-3,4,5-trimethoxyphenylacetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of alpha-isopropyl-alpha-[3-[N-[3-(3-hydroxymethylphenoxy)propyl]-N-methylamino]propyl]-3,4,5-trimethoxyphenylacetonitrile

There total 4 articles about alpha-isopropyl-alpha-[3-[N-[3-(3-hydroxymethylphenoxy)propyl]-N-methylamino]propyl]-3,4,5-trimethoxyphenylacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + alpha-isopropyl-alpha-[3-[N-[3-(3-hydroxymethylphenoxy)propyl]amino]propyl]-3,4,5-trimethoxyphenyl acetonitrile → alpha-isopropyl-alpha-[3-[N-[3-(3-hydroxymethylphenoxy)propyl]-N-methylamino]propyl]-3,4,5-trimethoxyphenylacetonitrile (103523-51-9)

Guidance literature:

With sodium borohydrid; In methanol; water;

Reference yield:

α-(2-formylethyl)-α-isopropyl-3,4,5-trimethoxybenzeneacetonitrile (66332-86-3) → alpha-isopropyl-alpha-[3-[N-[3-(3-hydroxymethylphenoxy)propyl]-N-methylamino]propyl]-3,4,5-trimethoxyphenylacetonitrile (103523-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) NaBH₄ / 1.) EtOH, 1.5 h, reflux, 2.) EtOH, ice water, 1 h, room temp.

2: 2.) NaBH₄ / 1.) MeOH, H₂O, 2 h, reflux, 2.) MeOH, ice water, 1 h, room temp.

With sodium tetrahydroborate;

DOI:10.1248/cpb.36.373

Reference yield:

3-[(3-hydroxymethyl)phenoxy]propanamine (72126-71-7) → alpha-isopropyl-alpha-[3-[N-[3-(3-hydroxymethylphenoxy)propyl]-N-methylamino]propyl]-3,4,5-trimethoxyphenylacetonitrile (103523-51-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) NaBH₄ / 1.) EtOH, 1.5 h, reflux, 2.) EtOH, ice water, 1 h, room temp.

2: 2.) NaBH₄ / 1.) MeOH, H₂O, 2 h, reflux, 2.) MeOH, ice water, 1 h, room temp.

With sodium tetrahydroborate;

DOI:10.1248/cpb.36.373

upstream raw materials:

formaldehyd

5-[3-(3-Hydroxymethyl-phenoxy)-propylamino]-2-isopropyl-2-(3,4,5-trimethoxy-phenyl)-pentanenitrile

α-(2-formylethyl)-α-isopropyl-3,4,5-trimethoxybenzeneacetonitrile

3-[(3-hydroxymethyl)phenoxy]propanamine

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