3-[5-chloro-7-(2-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]propionitrile

Base Information

Chemical Name:3-[5-chloro-7-(2-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]propionitrile
CAS No.:676132-02-8
Molecular Formula:C₁₇H₁₀Cl₂N₂O₃
Molecular Weight:361.184
Hs Code.:

Synonyms:3-[5-chloro-7-(2-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]propionitrile

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Chemical Property of 3-[5-chloro-7-(2-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]propionitrile

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Technology Process of 3-[5-chloro-7-(2-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]propionitrile

There total 5 articles about 3-[5-chloro-7-(2-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 107-13-1,25014-41-9
acrylonitrile

: 676131-87-6
5-chloro-7-(2-chlorobenzoyl)-2-oxo-3H-benzoxazole

: 676132-02-8
3-[5-chloro-7-(2-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]propionitrile

Guidance literature:: With triethylamine; In ethyl acetate; Heating;
DOI:10.1002/ardp.200300748

Reference yield:

: 609-65-4
o-chlorobenzoyl chloride

: 676132-02-8
3-[5-chloro-7-(2-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]propionitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: AlCl₃ / dimethylformamide / 0.25 h / 0 - 10 °C

1.2: dimethylformamide / 6 h / 120 °C

2.1: conc. HCl / 3 h / Heating

3.1: 64 percent / pyridine / 100 °C

4.1: 72 percent / Et₃N / ethyl acetate / Heating

With hydrogenchloride; aluminium trichloride; triethylamine; In pyridine; ethyl acetate; N,N-dimethyl-formamide; 1.1: Friedel-Crafts acylation / 4.1: Michael addition;
DOI:10.1002/ardp.200300748

Reference yield:

: 676131-84-3
2-acetylamino-4-chloro-6-(2-chlorobenzoyl)phenol

: 676132-02-8
3-[5-chloro-7-(2-chlorobenzoyl)-2-oxo-3H-benzoxazol-3-yl]propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: conc. HCl / 3 h / Heating

2: 64 percent / pyridine / 100 °C

3: 72 percent / Et₃N / ethyl acetate / Heating

With hydrogenchloride; triethylamine; In pyridine; ethyl acetate; 3: Michael addition;
DOI:10.1002/ardp.200300748