1-(4-Methylphenyl)pyrrolo[1,2-a]pyrazine

Base Information

Chemical Name:1-(4-Methylphenyl)pyrrolo[1,2-a]pyrazine
CAS No.:136927-47-4
Molecular Formula:C₁₄H₁₂N₂
Molecular Weight:208.263
Hs Code.:
DSSTox Substance ID:DTXSID901277524

Synonyms:1-(4-methylphenyl)pyrrolo[1,2-a]pyrazine;SCHEMBL9772563;DTXSID901277524;136927-47-4

Suppliers and Price of 1-(4-Methylphenyl)pyrrolo[1,2-a]pyrazine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(4-Methylphenyl)pyrrolo[1,2-a]pyrazine

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:1
Exact Mass:208.100048391
Heavy Atom Count:16
Complexity:233

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2=NC=CN3C2=CC=C3

Technology Process of 1-(4-Methylphenyl)pyrrolo[1,2-a]pyrazine

There total 2 articles about 1-(4-Methylphenyl)pyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 136927-64-5
1-chloropyrrolo[1,2-a]pyrazine

: 5720-05-8
4-methylphenylboronic acid

: 136927-47-4
1-p-tolylpyrrolo[1,2-a]pyrazine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; benzene; at 80 ℃; Inert atmosphere;
DOI:10.1021/ol5013313

Reference yield:

: 112758-97-1
1-(4-chlorophenyl)pyrrolo[1,2-a]pyrazine

: 136927-47-4
1-p-tolylpyrrolo[1,2-a]pyrazine

Guidance literature:

Reference yield:

: 136927-47-4
1-p-tolylpyrrolo[1,2-a]pyrazine

: (-)-2-benzyl-1-p-tolyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

: (+)-2-benzyl-1-p-tolyl-1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: acetone / 12 h / Reflux

2: hydrogen; bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R_ax,S,S)-C₃-TunePhos; caesium carbonate / tetrahydrofuran / 24 h / 20 °C / 20686.5 Torr / Autoclave

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; (R_ax,S,S)-C₃-TunePhos; hydrogen; caesium carbonate; In tetrahydrofuran; acetone;
DOI:10.1021/ol5013313