112758-97-1Relevant academic research and scientific papers
Iridium-catalyzed asymmetric hydrogenation of pyrrolo[1,2- a ]pyrazinium salts
Huang, Wen-Xue,Yu, Chang-Bin,Shi, Lei,Zhou, Yong-Gui
supporting information, p. 3324 - 3327 (2014/07/08)
Highly enantioselective iridium-catalyzed hydrogenation of pyrrolo[1,2-a]pyrazinium salts has been achieved, providing a direct access to chiral 1,2,3,4-tetrahydropyrrolo[1,2-a]pyrazine derivatives with up to 95% ee. The key feature of the reaction is the addition of cesium carbonate, which increases the conversion and prohibits the racemization pathway of products.
