4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid butyl ester

Base Information

Chemical Name:4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid butyl ester
CAS No.:1021703-38-7
Molecular Formula:C₂₉H₃₈ClN₅O₆
Molecular Weight:588.104
Hs Code.:

Synonyms:4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid butyl ester

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Chemical Property of 4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid butyl ester

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Technology Process of 4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid butyl ester

There total 15 articles about 4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1019929-10-2
butyl (S)-4-(2-amino-4-tert-butoxycarbonylbutyryl)piperazine-1-carboxylate

: 913952-59-7
6-chloro-2-phenylpyrimidine-4-carboxylic acid

: 1021703-38-7
4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid butyl ester

Guidance literature:: 6-chloro-2-phenylpyrimidine-4-carboxylic acid; With oxalyl dichloride; In acetonitrile; for 2h; Reflux;

butyl (S)-4-(2-amino-4-tert-butoxycarbonylbutyryl)piperazine-1-carboxylate; With triethylamine; In acetonitrile; at 0 - 20 ℃;

Reference yield:

: 913952-59-7
6-chloro-2-phenylpyrimidine-4-carboxylic acid

: 4-((S)-2-amino-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid butyl ester acetate

: 1021703-38-7
4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid butyl ester

Guidance literature:: 6-chloro-2-phenylpyrimidine-4-carboxylic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; In dichloromethane; at 20 ℃; for 0.166667h;

4-((S)-2-amino-4-tert-butoxycarbonyl-butyryl)-piperazine-1-carboxylic acid butyl ester acetate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 592-34-7
carbonochloridic acid, butyl ester

: 1021703-38-7
4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 20 °C

2: palladium on activated charcoal; hydrogen / ethanol / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane; tetrahydrofuran / 20 °C

4: palladium on activated charcoal; hydrogen / ethanol / 20 °C

5: triethylamine / acetonitrile / 0 - 20 °C

With palladium on activated charcoal; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2014.06.070