6-chloro-2-phenyl-pyrimidine-4-carboxylic acid

Base Information

• Chemical Name: 6-chloro-2-phenyl-pyrimidine-4-carboxylic acid
• CAS No.: 913952-59-7
• Molecular Formula: C11H7ClN2O2
• Molecular Weight: 234.642
• Hs Code.: 2933599090
• Mol file: 913952-59-7.mol

Synonyms:chlorophenylpyrimidinecarboxylicacid;6-chloro-2-phenyl-pyrimidine-4-carboxylic acid;

Chemical Property of 6-chloro-2-phenyl-pyrimidine-4-carboxylic acid

Chemical Property:

• PSA: 63.08000
• LogP: 2.49520
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

6-Chloro-2-phenylpyrimidine-4-carboxylic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 6-chloro-2-phenyl-pyrimidine-4-carboxylic acid

There total 6 articles about 6-chloro-2-phenyl-pyrimidine-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

C13H7ClN4 → 6-chloro-2-phenylpyrimidine-4-carboxylic acid (913952-59-7)

Guidance literature:

C₁₃H₇ClN₄; With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; at 20 ℃; for 0.25h; Molecular sieve;

With water; In tetrahydrofuran; at 20 ℃; for 0.25h; Reagent/catalyst; Temperature; Molecular sieve;

DOI:10.1055/s-0034-1380572

Reference yield: 83.0%

4-Chloro-6-hydroxymethyl-2-phenylpyrimidine (325685-75-4) → 6-chloro-2-phenylpyrimidine-4-carboxylic acid (913952-59-7)

Guidance literature:

With potassium permanganate; sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; for 3h;

DOI:10.1021/acs.jmedchem.5b00933

Reference yield:

6-methoxymethyl-2-phenylpyrimidin-4-ol (339278-89-6) → 6-chloro-2-phenylpyrimidine-4-carboxylic acid (913952-59-7)

Guidance literature:

Multi-step reaction with 3 steps

1: trichlorophosphate / 110 °C

2: boron tribromide / dichloromethane / 0 °C

3: potassium permanganate; sodium hydroxide / water; 1,4-dioxane / 20 °C

With potassium permanganate; boron tribromide; sodium hydroxide; trichlorophosphate; In 1,4-dioxane; dichloromethane; water;

DOI:10.1016/j.bmcl.2014.06.070

upstream raw materials:

4-Chloro-6-hydroxymethyl-2-phenylpyrimidine

benzamidin

6-methoxymethyl-2-phenylpyrimidin-4-ol

4-chloro-6-methoxymethyl-2-phenylpyrimidine

Downstream raw materials:

6-((S)-3-methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carboxylic acid

4-((S)-2-((6-chloro-2-phenylpyrimidine-4-carbonyl)amino)-4-diethoxyphosphorylbutyryl)piperazine-1-carboxylic acid butyl ester

4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid butyl ester

4-{(S)-4-tert-butoxycarbonyl-2-[(6-chloro-2-phenyl-pyrimidine-4-carbonyl)-amino]-butyryl}-piperazine-1-carboxylic acid ethyl ester

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