[3-((2R)-2-amino-propyl)-phenyl]-acetic acid methyl ester hydrochloride

Base Information

Chemical Name:[3-((2R)-2-amino-propyl)-phenyl]-acetic acid methyl ester hydrochloride
CAS No.:808768-84-5
Molecular Formula:C₁₂H₁₇NO₂*ClH
Molecular Weight:243.733
Hs Code.:

Synonyms:[3-((2R)-2-amino-propyl)-phenyl]-acetic acid methyl ester hydrochloride

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Chemical Property of [3-((2R)-2-amino-propyl)-phenyl]-acetic acid methyl ester hydrochloride

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Technology Process of [3-((2R)-2-amino-propyl)-phenyl]-acetic acid methyl ester hydrochloride

There total 4 articles about [3-((2R)-2-amino-propyl)-phenyl]-acetic acid methyl ester hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 792917-98-7
methyl [3-((2R)-2-{[(1R)-1-phenylethyl]amino}propyl)phenyl]acetate

: 808768-84-5
[3-((2R)-2-amino-propyl)-phenyl]-acetic acid methyl ester hydrochloride

Guidance literature:: With ammonium formate; palladium(II) hydroxide/carbon; at 75 ℃; for 1.5h;

Reference yield:

: 792917-99-8
methyl [3-(2-oxopropyl)phenyl]acetate

: 808768-84-5
[3-((2R)-2-amino-propyl)-phenyl]-acetic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 48 h / 20 °C

2: ammonium formate / palladium(II) hydroxide/carbon / 1.5 h / 75 °C

With ammonium formate; sodium tris(acetoxy)borohydride; acetic acid; palladium(II) hydroxide/carbon; In dichloromethane;

Reference yield:

: 1878-67-7
3-Bromophenylacetic acid

: 808768-84-5
[3-((2R)-2-amino-propyl)-phenyl]-acetic acid methyl ester hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol; acetyl chloride / 5 h / 0 - 20 °C

2.1: tributyltin methoxide; tris-(o-tolyl)phosphine / palladium diacetate / toluene / 5 h / 100 °C

2.2: 0.25 h

3.1: sodium tris(acetoxy)borohydride; acetic acid / dichloromethane / 48 h / 20 °C

4.1: ammonium formate / palladium(II) hydroxide/carbon / 1.5 h / 75 °C

With methanol; ammonium formate; tributyltin methoxide; sodium tris(acetoxy)borohydride; acetic acid; acetyl chloride; tris-(o-tolyl)phosphine; palladium diacetate; palladium(II) hydroxide/carbon; In dichloromethane; toluene;