2-{1-[4-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-but-3-enyloxy}-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan

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Chemical Name:2-{1-[4-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-but-3-enyloxy}-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan
CAS No.:912805-58-4
Molecular Formula:C₄₅H₈₈O₇Si₄
Molecular Weight:853.532
Hs Code.:

2-{1-[4-benzyloxy-2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-but-3-enyloxy}-3,4-bis-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-(<i>tert</i>-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan

Synonyms:2-{1-[4-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-but-3-enyloxy}-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan

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Chemical Property of 2-{1-[4-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-but-3-enyloxy}-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan

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Technology Process of 2-{1-[4-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-but-3-enyloxy}-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan

There total 7 articles about 2-{1-[4-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-but-3-enyloxy}-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 912805-58-4
2-{1-[4-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-but-3-enyloxy}-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan

Guidance literature:: Multi-step reaction with 6 steps

1.1: NaH / tetrahydrofuran

1.2: 70 percent / n-BuLi

2.1: 100 percent / hydrogen / Ru₂Cl₂[(R)-BINAP]2*Et₃N / methanol / 66 h / 23 °C / 42923.3 Torr

3.1: 99 percent / imidazole / dimethylformamide / 15 h / 23 °C

4.1: 93 percent / DIBAL-H / petroleum ether; toluene / 0.08 h / -78 °C

5.1: n-butyllithium; potassium tert-butoxide / petroleum ether; tetrahydrofuran / -78 - -45 °C

5.2: boron trifluoride diethyl etherate / (+)-B-methoxydiisopinocamphenylborane / petroleum ether; tetrahydrofuran; diethyl ether / -78 °C

5.3: petroleum ether; tetrahydrofuran; diethyl ether / 8.5 h

6.1: 162 mg / CH₂Cl₂; toluene / 22.5 h / -45 - 23 °C

With 1H-imidazole; n-butyllithium; potassium tert-butylate; hydrogen; sodium hydride; diisobutylaluminium hydride; Ru₂Cl₂[(R)-BINAP]2*Et₃N; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; Petroleum ether;
DOI:10.1021/ja062364i

Reference yield:

: 106064-33-9
isobutyl 5-(benzyloxy)-3-oxopentanoate

: 912805-58-4
2-{1-[4-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-but-3-enyloxy}-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / hydrogen / Ru₂Cl₂[(R)-BINAP]2*Et₃N / methanol / 66 h / 23 °C / 42923.3 Torr

2.1: 99 percent / imidazole / dimethylformamide / 15 h / 23 °C

3.1: 93 percent / DIBAL-H / petroleum ether; toluene / 0.08 h / -78 °C

4.1: n-butyllithium; potassium tert-butoxide / petroleum ether; tetrahydrofuran / -78 - -45 °C

4.2: boron trifluoride diethyl etherate / (+)-B-methoxydiisopinocamphenylborane / petroleum ether; tetrahydrofuran; diethyl ether / -78 °C

4.3: petroleum ether; tetrahydrofuran; diethyl ether / 8.5 h

5.1: 162 mg / CH₂Cl₂; toluene / 22.5 h / -45 - 23 °C

With 1H-imidazole; n-butyllithium; potassium tert-butylate; hydrogen; diisobutylaluminium hydride; Ru₂Cl₂[(R)-BINAP]2*Et₃N; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; Petroleum ether;
DOI:10.1021/ja062364i

Reference yield:

: 124010-06-6
(R)-(+)-5-(benzyloxy)-3-(tert-butyldimethylsilyloxy)pentanal

: 912805-58-4
2-{1-[4-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-butyl]-2-methyl-but-3-enyloxy}-3,4-bis-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium; potassium tert-butoxide / petroleum ether; tetrahydrofuran / -78 - -45 °C

1.2: boron trifluoride diethyl etherate / (+)-B-methoxydiisopinocamphenylborane / petroleum ether; tetrahydrofuran; diethyl ether / -78 °C

1.3: petroleum ether; tetrahydrofuran; diethyl ether / 8.5 h

2.1: 162 mg / CH₂Cl₂; toluene / 22.5 h / -45 - 23 °C

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran; dichloromethane; toluene; Petroleum ether;
DOI:10.1021/ja062364i