1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-1H-pyrrole-3-carbaldehyde

Base Information

Chemical Name:1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-1H-pyrrole-3-carbaldehyde
CAS No.:856689-47-9
Molecular Formula:C₃₃H₄₅NO₄Si
Molecular Weight:547.81
Hs Code.:

Synonyms:1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-1H-pyrrole-3-carbaldehyde

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Chemical Property of 1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-1H-pyrrole-3-carbaldehyde

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Technology Process of 1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-1H-pyrrole-3-carbaldehyde

There total 7 articles about 1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-1H-pyrrole-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S,3S)-3-{[tert-butyl(dimethyl)silyl]oxy}-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)propyl methanesulfonate

: 7126-39-8
pyrrole-3-carboxaldehyde

: 856689-47-9
1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-1H-pyrrole-3-carbaldehyde

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 80 - 100 ℃; for 3.5h;
DOI:10.1021/acsmedchemlett.7b00383

Reference yield:

: C₂₂H₂₃NO₃

: 856689-47-9
1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-1H-pyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; chloro-trimethyl-silane; magnesium chloride / ethyl acetate / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 °C

3: lithium borohydride / tetrahydrofuran; water / 20 °C

4: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

5: caesium carbonate / N,N-dimethyl-formamide / 3.5 h / 80 - 100 °C

With 2,6-dimethylpyridine; lithium borohydride; chloro-trimethyl-silane; caesium carbonate; triethylamine; magnesium chloride; In tetrahydrofuran; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.7b00383

Reference yield:

: C₃₂H₃₅NO₆

: 856689-47-9
1-[(2S,3S)-2-(2,3-dihydro-1H-inden-2-ylmethyl)-3-(3,5-dimethoxy-4-methylphenyl)-3-hydroxypropyl]-1H-pyrrole-3-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1: 2,6-dimethylpyridine / dichloromethane / 2 h / 0 °C

2: lithium borohydride / tetrahydrofuran; water / 20 °C

3: triethylamine / tetrahydrofuran / 0.5 h / 0 °C

4: caesium carbonate / N,N-dimethyl-formamide / 3.5 h / 80 - 100 °C

With 2,6-dimethylpyridine; lithium borohydride; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.7b00383