BUTANOIC ACID, 4-CYANO-3-HYDROXY-, METHYL ESTER, (3R)-

Base Information

Chemical Name:BUTANOIC ACID, 4-CYANO-3-HYDROXY-, METHYL ESTER, (3R)-
CAS No.:141942-84-9
Molecular Formula:C6H9 N O3
Molecular Weight:143.142
Hs Code.:
Mol file:141942-84-9.mol

Synonyms:Butanoicacid, 4-cyano-3-hydroxy-, methyl ester, (R)-

Suppliers and Price of BUTANOIC ACID, 4-CYANO-3-HYDROXY-, METHYL ESTER, (3R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of BUTANOIC ACID, 4-CYANO-3-HYDROXY-, METHYL ESTER, (3R)-

Chemical Property:

PSA：70.32000
LogP:-0.17592

Purity/Quality:: 98%Min ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of BUTANOIC ACID, 4-CYANO-3-HYDROXY-, METHYL ESTER, (3R)-

There total 2 articles about BUTANOIC ACID, 4-CYANO-3-HYDROXY-, METHYL ESTER, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 773837-37-9
sodium cyanide

: 940-47-6
1-chloro-3-phenoxyacetone

: 86728-93-0
methyl (S)-4-chloro-3-hydroxybutanoate

: 141942-84-9
(R)-methyl (3-hydroxy-4-cyano)-butanoate

Guidance literature:: 1-chloro-3-phenoxyacetone; With alcohol dehydrogenase from Lactobacillus brevis; NADPH; isopropyl alcohol; at 30 ℃; for 6h; pH=7.5; aq. buffer; Enzymatic reaction;

sodium cyanide; With halohydrin dehalogenase from Mycobacterium sp. GP₁; at 30 ℃; for 18h; pH=7.5; optical yield given as %ee; aq. buffer; Enzymatic reaction;
DOI:10.1002/ejoc.200900091

Reference yield:

: 4509-09-5
Methyl (+/-)-3,4-epoxybutanoate

: 143-33-9,25596-52-5
sodium cyanide

: 88496-70-2
methyl (R)-4-chloro-3-hydroxybutyrate

: 86728-93-0
methyl (S)-4-chloro-3-hydroxybutanoate

: 141942-84-9
(R)-methyl (3-hydroxy-4-cyano)-butanoate

: 150966-86-2
(S)-3-hydroxy-4-cyanobutyric acid methylester

Guidance literature:: With halohydrin dehalogenase Trp₂₄₉Phe mutant; Tris-SO₄ buffer; In dimethyl sulfoxide; at 22 ℃; for 1.5h; pH=7.5; Further Variations:; Reagents; reaction times; Product distribution;
DOI:10.1021/ol061369h

Reference yield:

: 141942-84-9
(R)-methyl (3-hydroxy-4-cyano)-butanoate

: 125971-93-9
(3R,5R)-tert-butyl-6-cyano-3,5-dihydroxyhexanoate

Guidance literature:: Multi-step reaction with 2 steps

1: hexane; tetrahydrofuran

2: NaBH₄, B(Et)2OMe / methanol / -90 °C

With sodium tetrahydroborate; diethyl methoxy borane; In tetrahydrofuran; methanol; hexane;
DOI:10.1016/S0040-4039(00)74189-X