3-(Pyridin-2-yl)propan-1-amine

Base Information

• Chemical Name: 3-(Pyridin-2-yl)propan-1-amine
• CAS No.: 15583-16-1
• Molecular Formula: C8H12N2
• Molecular Weight: 136.197
• Hs Code.: 2933399090
• European Community (EC) Number: 818-125-1
• DSSTox Substance ID: DTXSID80390198
• Nikkaji Number: J989.641D
• Wikidata: Q82186687
• ChEMBL ID: CHEMBL4548322
• Mol file: 15583-16-1.mol

Synonyms:15583-16-1;3-(pyridin-2-yl)propan-1-amine;3-(2-pyridyl)propylamine;3-(2-Pyridinyl)propylamine;3-pyridin-2-ylpropan-1-amine;3-Pyridin-2-yl-propylamine;2-Pyridinepropanamine;2-(3-AMINOPROPYL)PYRIDINE;MFCD06809629;3-(2-PYRIDINYL)-1-PROPANAMINE;(3-PYRIDIN-2-YLPROPYL)AMINE;2-Pyridine-1-propanamine;3-Pyridin-2-ylpropylamine;2-(3-aminopropyl) pyridine;3-(pyridin-2-yl)propylamine;SCHEMBL311512;3-(2-pyridyl)propan-1-amine;CHEMBL4548322;DTXSID80390198;UGYRJDSEKCYZKI-UHFFFAOYSA-N;HMS1704I14;3-(pyridine-2-yl)propan-1-amine;STK688555;AKOS000505639;AB30458;AS-39390;SY022423;A3425;BB 0251676;CS-0006435;FT-0743822;EN300-109844;Z600381818

Chemical Property of 3-(Pyridin-2-yl)propan-1-amine

Chemical Property:

• Vapor Pressure: 0.0771mmHg at 25°C
• Refractive Index: 1.532
• Boiling Point: 227.5 °C at 760 mmHg
• PKA: 9.88±0.10(Predicted)
• Flash Point: 112 °C
• PSA: 38.91000
• Density: 1.003 g/cm³
• LogP: 1.67320
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 136.100048391
• Heavy Atom Count: 10
• Complexity: 83.3

Purity/Quality:

98%min ^*data from raw suppliers

3-(Pyridin-2-yl)propan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)CCCN
• Uses: 3-(pyridin-2-yl)propan-1-amine is used in the preparation of 2,4,6-s-triazine derivatives with biological and anti-malarial properties.

Technology Process of 3-(Pyridin-2-yl)propan-1-amine

There total 6 articles about 3-(Pyridin-2-yl)propan-1-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-[3-(pyridin-2-yl)propyl]isoindoline-1,3-dione (838892-94-7) → 3-(pyridin-2-yl)propan-1-amine (15583-16-1)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃;

DOI:10.1039/c3md00245d

Reference yield: 60.0%

2-(2-Cyanoethyl)pyridine (35549-47-4) → 3-(pyridin-2-yl)propan-1-amine (15583-16-1)

Guidance literature:

DOI:10.1002/hlca.19820650621

Reference yield:

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) → 3-(pyridin-2-yl)propan-1-amine (15583-16-1)

Guidance literature:

With potassium cyanide; H₂; acetic anhydride; Ra-Ni; In ethanol; water;

upstream raw materials:

2-(2-Cyanoethyl)pyridine

2-[3-(pyridin-2-yl)propyl]isoindoline-1,3-dione

3-(pyridin-2-yl)-propanol

2-(2-chloroethyl)pyridine

Downstream raw materials:

N₁-(3,3-diphenylpropanoyl)-N₂-[3-(pyridin-2-yl)propyl]guanidine

N₁-(3-phenylbutanoyl)-N₂-[3-(pyridin-2-yl)propyl]guanidine

Refernces

• 1、 Rapi, Zsolt,Bak?3, P??ter,Drahos, L??szl?3,Keglevich, Gy??rgy. "Side-arm effect of a methyl ?±-D-glucopyranoside based lariat ether catalysts in asymmetric syntheses". . p. 63 - 71. Retrieved 2015/02/19.
• 2、 -. "2,6-Diaminopyridine Compounds Suitable For Treating Diseases Associated With Amyloid Or Amyloid-Like Proteins Or For Treating Or Preventing Ocular Diseases Or Conditions Associated With A Pathological Abnormality/Change In The Tissue Of The Visual System". Page/Page column 40. . Retrieved 2011/05/03.