2-Cyanoethylpyridine

Base Information

• Chemical Name: 2-Cyanoethylpyridine
• CAS No.: 35549-47-4
• Molecular Formula: C8H8N2
• Molecular Weight: 132.165
• Hs Code.: 2933399090
• Mol file: 35549-47-4.mol

Synonyms:3-(2-Pyridyl)propionitrile;2-Cyanoethylpyridine;

Chemical Property of 2-Cyanoethylpyridine

Chemical Property:

• Vapor Pressure: 0.005mmHg at 25°C
• Refractive Index: 1.525
• Boiling Point: 277.059 °C at 760 mmHg
• Flash Point: 103.96 °C
• PSA: 36.68000
• Density: 1.054 g/cm³
• LogP: 1.53778

Purity/Quality:

98%min ^*data from raw suppliers

3-(2-pyridinyl)propanenitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Cyanoethylpyridine

There total 17 articles about 2-Cyanoethylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-vinylpyridine (100-69-6,25014-15-7,27476-03-5,329041-71-6) + zinc(II) cyanide (557-21-1) → 2-(2-Cyanoethyl)pyridine (35549-47-4)

Guidance literature:

With nickel(II) chloride hexahydrate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; zinc; In 1,4-dioxane; water; at 80 ℃; Reagent/catalyst; Glovebox; Inert atmosphere;

Reference yield: 82.0%

3-(2-pyridinyl)-2-propenenitrile (100949-40-4) → 2-(2-Cyanoethyl)pyridine (35549-47-4)

Guidance literature:

With sodium tetrahydroborate; In isopropyl alcohol; at 80 ℃; for 14h;

Reference yield: 80.0%

3-(pyridin-2-yl)-propanol (2859-68-9) → 2-(2-Cyanoethyl)pyridine (35549-47-4)

Guidance literature:

With 2,3'-bipyridine; ammonium hydroxide; copper(l) iodide; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; In ethanol; at 20 ℃; for 24h;

DOI:10.1021/ol400459y

upstream raw materials:

2-vinylpyridine

hydrogen cyanide

potassium cyanide

2-(2-bromoethyl)pyridine

Downstream raw materials:

1-phenyl-3-(pyridin-2-yl)propan-1-one

3-(pyridin-2-yl)propanoic acid

indolizidine

ethyl 3-(2-pyridinyl)propanoate

Refernces

• 1、 Bhawal, Benjamin N.,Jelmini, Nicola,Morandi, Bill,Reisenbauer, Julia C.. "Development of an Operationally Simple, Scalable, and HCN-Free Transfer Hydrocyanation Protocol Using an Air-Stable Nickel Precatalyst". supporting information. . Retrieved 2022/03/01.
• 2、 Bhawal, Benjamin N.,Ehinger, Christian,Morandi, Bill,Reisenbauer, Julia C.. "Overcoming Selectivity Issues in Reversible Catalysis: A Transfer Hydrocyanation Exhibiting High Kinetic Control". supporting information. p. 10914 - 10920. Retrieved 2020/07/13.