N-(1-{6-[(3-cyclopropyl-4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethyl)acetamide

Base Information

Chemical Name:N-(1-{6-[(3-cyclopropyl-4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethyl)acetamide
CAS No.:1224716-61-3
Molecular Formula:C₂₄H₂₇NO₄
Molecular Weight:393.483
Hs Code.:

Synonyms:N-(1-{6-[(3-cyclopropyl-4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethyl)acetamide

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Chemical Property of N-(1-{6-[(3-cyclopropyl-4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethyl)acetamide

Chemical Property:

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Technology Process of N-(1-{6-[(3-cyclopropyl-4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethyl)acetamide

There total 7 articles about N-(1-{6-[(3-cyclopropyl-4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1224716-57-7
N-(1-{6-[(3-bromo-4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethyl)acetamide

: 411235-57-9
cyclopropylboronic acid

: 1224716-61-3
N-(1-{6-[(3-cyclopropyl-4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethyl)acetamide

Guidance literature:: With potassium tert-butylate; tricyclohexylphosphine; palladium diacetate; In toluene; at 100 ℃;

Reference yield:

: 1224717-02-5
1-[6-(benzyloxy)-1-benzofuran-2-yl]ethanol

: 1224716-61-3
N-(1-{6-[(3-cyclopropyl-4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 3 h / 0 - 20 °C

2: triphenylphosphine; water / tetrahydrofuran / Reflux

3: pyridine / dichloromethane / 1 h / 20 °C

4: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 100 °C

6: tricyclohexylphosphine; potassium tert-butylate / palladium diacetate / toluene / 100 °C

With pyridine; diphenyl phosphoryl azide; potassium tert-butylate; water; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 412300-33-5
1-(6-(benzyloxy)benzofuran-2-yl)ethan-1-one

: 1224716-61-3
N-(1-{6-[(3-cyclopropyl-4-ethoxybenzyl)oxy]-1-benzofuran-2-yl}ethyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: sodium tetrahydroborate / methanol / 1 h / 20 °C

2: diphenyl phosphoryl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / toluene / 3 h / 0 - 20 °C

3: triphenylphosphine; water / tetrahydrofuran / Reflux

4: pyridine / dichloromethane / 1 h / 20 °C

5: hydrogen / palladium 10% on activated carbon / methanol / 5 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 100 °C

7: tricyclohexylphosphine; potassium tert-butylate / palladium diacetate / toluene / 100 °C

With pyridine; sodium tetrahydroborate; diphenyl phosphoryl azide; potassium tert-butylate; water; hydrogen; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;