N-(N⁶-((benzyloxy)carbonyl)-N₂-(tert-butoxycarbonyl)-L-lysyl)-4R-hydroxy-L-proline methyl ester

Base Information

• Chemical Name: N-(N⁶-((benzyloxy)carbonyl)-N₂-(tert-butoxycarbonyl)-L-lysyl)-4R-hydroxy-L-proline methyl ester
• CAS No.: 81081-42-7
• Molecular Formula: C₂₅H₃₇N₃O₈
• Molecular Weight: 507.584

Synonyms:N-(N⁶-((benzyloxy)carbonyl)-N₂-(tert-butoxycarbonyl)-L-lysyl)-4R-hydroxy-L-proline methyl ester

Chemical Property of N-(N⁶-((benzyloxy)carbonyl)-N₂-(tert-butoxycarbonyl)-L-lysyl)-4R-hydroxy-L-proline methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N⁶-((benzyloxy)carbonyl)-N₂-(tert-butoxycarbonyl)-L-lysyl)-4R-hydroxy-L-proline methyl ester

There total 2 articles about N-(N⁶-((benzyloxy)carbonyl)-N₂-(tert-butoxycarbonyl)-L-lysyl)-4R-hydroxy-L-proline methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.7%

Boc-Lys(Z)-OH (2389-45-9) + (R)-4-hydroxy-L-proline ethyl ester (1499-56-5,775275-31-5,790644-51-8,754962-86-2) → N-(N6-((benzyloxy)carbonyl)-N2-(tert-butoxycarbonyl)-L-lysyl)-4R-hydroxy-L-proline methyl ester (81081-42-7)

Guidance literature:

Boc-Lys(Z)-OH; (R)-4-hydroxy-L-proline ethyl ester; With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 0.666667h;

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 24.5h;

DOI:10.1016/j.tet.2012.02.015

Reference yield: 68.0%

Boc-Lys(Z)-OH (2389-45-9) + L-4-hydroxyproline methyl ester hydrochloride (40216-83-9) → N-(N6-((benzyloxy)carbonyl)-N2-(tert-butoxycarbonyl)-L-lysyl)-4R-hydroxy-L-proline methyl ester (81081-42-7)

Guidance literature:

With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1021/acs.joc.9b00114

Reference yield: 81.6%

N-(N6-((benzyloxy)carbonyl)-N2-(tert-butoxycarbonyl)-L-lysyl)-4R-hydroxy-L-proline methyl ester (81081-42-7) + Boc-hTyr (198473-94-8) → N-Boc-hTyr-Lys(Nε-Cbz)-Pro(4R-OH)-OMe (1371578-05-0)

Guidance literature:

N-(N⁶-((benzyloxy)carbonyl)-N₂-(tert-butoxycarbonyl)-L-lysyl)-4R-hydroxy-L-proline methyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.666667h;

Boc-hTyr; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 24.6667h;

DOI:10.1016/j.tet.2012.02.015

upstream raw materials:

Boc-Lys(Z)-OH

(R)-4-hydroxy-L-proline ethyl ester

L-4-hydroxyproline methyl ester hydrochloride

Downstream raw materials:

cyclo-[Orn(Nα-6-heptyloxy-2-naphthoyl)-Thr-Pro(4S-N3)-hTyr-Lys(Nε-Cbz)-Pro(4R-OH)]

cyclo-[Orn(Nα-6-octyloxy-2-naphthoyl)-Thr-Pro(4S-N3)-hTyr-Lys(Nε-Cbz)-Pro(4R-OH)]

cyclo-[Orn(Nα-6-hexyloxy-2-naphthoyl)-Lys(Nε-Cbz)-Pro(4R-OH)-hTyr-Thr-Pro(4S-N3)]

Nδ-Boc-Orn(Nα-6-hexyloxy-2-naphthoyl)-Lys(Nε-Cbz)-Pro(4R-OH)-OMe

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 81081-42-7 N-(N⁶-((benzyloxy)carbonyl)-N₂-(tert-butoxycarbonyl)-L-lysyl)-4R-hydroxy-L-proline methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send