BOC-HOMO-L-TYROSINE

Base Information

• Chemical Name: BOC-HOMO-L-TYROSINE
• CAS No.: 198473-94-8
• Molecular Formula: C₁₅H₂₁NO₅
• Molecular Weight: 295.335
• Mol file: 198473-94-8.mol

Synonyms:Benzenebutanoicacid, a-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-, (S)-

Chemical Property of BOC-HOMO-L-TYROSINE

Chemical Property:

• Vapor Pressure: 1.26E-10mmHg at 25°C
• Boiling Point: 495.3oC at 760 mmHg
• PKA: 3.98±0.10(Predicted)
• Flash Point: 253.3oC
• PSA: 99.35000
• Density: 1.212g/cm3
• LogP: 2.50710
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

BOC-HOMO-L-TYROSINE 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BOC-HOMO-L-TYROSINE

There total 3 articles about BOC-HOMO-L-TYROSINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.5%

di-tert-butyl dicarbonate (24424-99-5) + (R)-homotyrosine hydrobromide (185617-14-5) → Boc-D-hTyr-OH (198473-94-8)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 0 - 20 ℃; for 2.16667h; pH=Ca. 8.5;

DOI:10.3109/14756366.2016.1172574

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + homo-p-(R)-tyrosine (749828-81-7,185062-84-4) → Boc-D-hTyr-OH (198473-94-8)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃;

DOI:10.1021/jacs.0c02956

Reference yield:

→ Boc-D-hTyr-OH (198473-94-8)

Guidance literature:

upstream raw materials:

di-tert-butyl dicarbonate

(R)-homotyrosine hydrobromide

homo-p-(R)-tyrosine

Refernces

• 1、 Maiwald, Alexander,Hammami, Maya,Wagner, Sebastian,Heine, Andreas,Klebe, Gerhard,Steinmetzer, Torsten. "Changing the selectivity profile–from substrate analog inhibitors of thrombin and factor Xa to potent matriptase inhibitors". . p. 89 - 97. Retrieved 2016/12/03.