1,1,1-trifluoro-2-(4-(4-(phenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Base Information

Chemical Name:1,1,1-trifluoro-2-(4-(4-(phenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol
CAS No.:1361216-13-8
Molecular Formula:C₁₉H₂₁F₃N₂O₃S
Molecular Weight:414.449
Hs Code.:

Synonyms:1,1,1-trifluoro-2-(4-(4-(phenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Suppliers and Price of 1,1,1-trifluoro-2-(4-(4-(phenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

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Chemical Property of 1,1,1-trifluoro-2-(4-(4-(phenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Chemical Property:

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Technology Process of 1,1,1-trifluoro-2-(4-(4-(phenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

There total 2 articles about 1,1,1-trifluoro-2-(4-(4-(phenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361216-14-9
1-(4-bromophenyl)-4-(phenylsulfonyl)piperazine

: 684-16-2
Hexafluoroacetone

: 1361216-13-8
1,1,1-trifluoro-2-(4-(4-(phenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Guidance literature:: 1-(4-bromophenyl)-4-(phenylsulfonyl)piperazine; With n-butyllithium; In tetrahydrofuran; hexanes; at -78 ℃; for 0.5h;

Hexafluoroacetone; In tetrahydrofuran; hexanes; at -78 ℃; for 1h;

With water; ammonium chloride; In tetrahydrofuran; hexanes;

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1361216-13-8
1,1,1-trifluoro-2-(4-(4-(phenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 0.25 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C

2.2: 1 h / -78 °C

With n-butyllithium; triethylamine; In tetrahydrofuran; hexanes; dichloromethane;