(1R,2R)-N-[(1S)-1-cyano-3-methoxypropyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

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Chemical Name:(1R,2R)-N-[(1S)-1-cyano-3-methoxypropyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide
CAS No.:639792-08-8
Molecular Formula:C₂₃H₃₁FN₄O₃
Molecular Weight:430.523
Hs Code.:

Synonyms:(1R,2R)-N-[(1S)-1-cyano-3-methoxypropyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

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Chemical Property of (1R,2R)-N-[(1S)-1-cyano-3-methoxypropyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

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Technology Process of (1R,2R)-N-[(1S)-1-cyano-3-methoxypropyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

There total 7 articles about (1R,2R)-N-[(1S)-1-cyano-3-methoxypropyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (1R,2R)-N-[(1S)-1-carboxamide-3-methoxypropyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl]carbonyl} cyclohexanecarboxamide

: 639792-08-8
(1R,2R)-N-[(1S)-1-cyano-3-methoxypropyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

Guidance literature:: With oxalyl dichloride; N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h;

With pyridine; for 0.0833333h;

(1R,2R)-N-[(1S)-1-carboxamide-3-methoxypropyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl]carbonyl} cyclohexanecarboxamide; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 2h;

Reference yield:

: 639792-12-4
(1R, 2R)-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxylic acid

: 639792-08-8
(1R,2R)-N-[(1S)-1-cyano-3-methoxypropyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(7-azabenzotriazol-1-yl)-N,N, N', N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 0 °C

1.2: 18 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / 0.08 h / 0 °C

2.2: 0.08 h

2.3: 2 h / 0 °C

With oxalyl dichloride; O-(7-azabenzotriazol-1-yl)-N,N, N', N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1-methyl-pyrrolidin-2-one;

Reference yield:

: 96894-64-3
(1R,2R)-1,2-cyclohexanedicarboxylic acid monomethyl ester

: 639792-08-8
(1R,2R)-N-[(1S)-1-cyano-3-methoxypropyl]-2-{[4-(4-fluorophenyl) piperazin-1-yl] carbonyl} cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 18 h / 20 °C

2.1: sodium hydroxide / methanol; water / 24 h / 55 °C

3.1: O-(7-azabenzotriazol-1-yl)-N,N, N', N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 1 h / 0 °C

3.2: 18 h / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / 0.08 h / 0 °C

4.2: 0.08 h

4.3: 2 h / 0 °C

With sodium hydroxide; oxalyl dichloride; O-(7-azabenzotriazol-1-yl)-N,N, N', N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In 1-methyl-pyrrolidin-2-one; methanol; water;