D-Proline, 4-amino-1-(phenylsulfonyl)-, methyl ester, trans-

Base Information

Chemical Name:D-Proline, 4-amino-1-(phenylsulfonyl)-, methyl ester, trans-
CAS No.:121148-02-5
Molecular Formula:C₁₂H₁₆N₂O₄S
Molecular Weight:284.336
Hs Code.:
DSSTox Substance ID:DTXSID901186228

Synonyms:SCHEMBL9507074;DTXSID901186228;D-Proline, 4-amino-1-(phenylsulfonyl)-, methyl ester, trans-;121148-02-5

Suppliers and Price of D-Proline, 4-amino-1-(phenylsulfonyl)-, methyl ester, trans-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of D-Proline, 4-amino-1-(phenylsulfonyl)-, methyl ester, trans-

Chemical Property:

XLogP3:0.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:284.08307817
Heavy Atom Count:19
Complexity:426

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1CC(CN1S(=O)(=O)C2=CC=CC=C2)N
Isomeric SMILES:COC(=O)[C@H]1C[C@@H](CN1S(=O)(=O)C2=CC=CC=C2)N

Technology Process of D-Proline, 4-amino-1-(phenylsulfonyl)-, methyl ester, trans-

There total 6 articles about D-Proline, 4-amino-1-(phenylsulfonyl)-, methyl ester, trans- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121147-98-6
methyl (2R,4S)-4-azido-1-(phenylsulfonyl)-2-pyrrolidinecarboxylate

: 121148-02-5
(2R,4S)-4-Amino-1-benzenesulfonyl-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 3h; under 2280 Torr;
DOI:10.1016/S0968-0896(01)00397-2

Reference yield:

: 114676-59-4
(2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride

: 121148-02-5
(2R,4S)-4-Amino-1-benzenesulfonyl-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / CH₂Cl₂ / 3 h / 0 - 5 °C

2: 5.10 g / triethylamine / CH₂Cl₂ / 0.5 h / 0 - 5 °C

3: 91 percent / sodium azide / dimethylsulfoxide / 90 °C

4: H₂ / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr

With sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0968-0896(01)00397-2

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 121148-02-5
(2R,4S)-4-Amino-1-benzenesulfonyl-pyrrolidine-2-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / CH₂Cl₂ / 3 h / 0 - 5 °C

2: 5.10 g / triethylamine / CH₂Cl₂ / 0.5 h / 0 - 5 °C

3: 91 percent / sodium azide / dimethylsulfoxide / 90 °C

4: H₂ / 10 percent Pd/C / methanol / 3 h / 20 °C / 2280 Torr

With sodium azide; hydrogen; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0968-0896(01)00397-2