4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethyl carbamoyl)-1H-indazol-3-yl)cyclohex-3-enecarboxylic acid

Base Information

Chemical Name:4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethyl carbamoyl)-1H-indazol-3-yl)cyclohex-3-enecarboxylic acid
CAS No.:1561949-38-9
Molecular Formula:C₂₅H₂₁ClF₃N₃O₄
Molecular Weight:519.908
Hs Code.:

Synonyms:4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethyl carbamoyl)-1H-indazol-3-yl)cyclohex-3-enecarboxylic acid

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Chemical Property of 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethyl carbamoyl)-1H-indazol-3-yl)cyclohex-3-enecarboxylic acid

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Technology Process of 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethyl carbamoyl)-1H-indazol-3-yl)cyclohex-3-enecarboxylic acid

There total 3 articles about 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethyl carbamoyl)-1H-indazol-3-yl)cyclohex-3-enecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1561949-64-1
methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethylcarbamoyl)-1H-indazol-3-yl)cyclohex-3-enecarboxylate

: 1561949-38-9
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethyl carbamoyl)-1H-indazol-3-yl)cyclohex-3-enecarboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

: 170487-40-8
1H-indazole-6-carboxylic acid methyl ester

: 1561949-38-9
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethyl carbamoyl)-1H-indazol-3-yl)cyclohex-3-enecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: iodine; potassium hydroxide / N,N-dimethyl acetamide / 1 h / 20 °C / Cooling with ice

2: dmap; triethylamine / dichloromethane / 20 °C

3: lithium hydroxide; water / tetrahydrofuran / 20 °C

4: triethylamine; ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) / dichloromethane / 2 h / 20 °C

5: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2 h / 95 °C / Microwave irradiation

6: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 20 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; water; iodine; potassium acetate; triethylamine; ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V); potassium hydroxide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water;

Reference yield:

: 18595-18-1
3-amino-4-methyl benzoic acid methyl ester

: 1561949-38-9
4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethyl carbamoyl)-1H-indazol-3-yl)cyclohex-3-enecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1: acetic acid; sodium nitrite / water / 20 °C / Cooling with ice

2: iodine; potassium hydroxide / N,N-dimethyl acetamide / 1 h / 20 °C / Cooling with ice

3: dmap; triethylamine / dichloromethane / 20 °C

4: lithium hydroxide; water / tetrahydrofuran / 20 °C

5: triethylamine; ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) / dichloromethane / 2 h / 20 °C

6: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 2 h / 95 °C / Microwave irradiation

7: water; lithium hydroxide monohydrate / tetrahydrofuran / 2 h / 20 °C

With dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; lithium hydroxide monohydrate; water; iodine; potassium acetate; acetic acid; triethylamine; ((3H-[1,2,3]triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V); potassium hydroxide; lithium hydroxide; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl acetamide; water;