Technology Process of 4-(benzofuran-2-yl)-1-benzylpiperidine
There total 5 articles about 4-(benzofuran-2-yl)-1-benzylpiperidine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-(benzofuran-2-yl)piperidine; benzaldehyde;
With
triethylamine;
In
acetic acid; N,N-dimethyl-formamide;
for 0.5h;
With
sodium tris(acetoxy)borohydride;
In
acetic acid; N,N-dimethyl-formamide;
for 4h;
DOI:10.1016/j.ejmech.2021.113541
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 6 h / -78 - -40 °C / Inert atmosphere
2.1: trifluoroacetic acid; triethylsilane / dichloromethane / 20 - 40 °C / Inert atmosphere
3.1: triethylamine / acetic acid; N,N-dimethyl-formamide / 0.5 h
3.2: 4 h
With
triethylsilane; n-butyllithium; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2021.113541
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere
1.2: 6 h / -78 - -40 °C / Inert atmosphere
2.1: trifluoroacetic acid; triethylsilane / dichloromethane / 20 - 40 °C / Inert atmosphere
3.1: triethylamine / acetic acid; N,N-dimethyl-formamide / 0.5 h
3.2: 4 h
With
triethylsilane; n-butyllithium; triethylamine; trifluoroacetic acid;
In
tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2021.113541
