5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione

Base Information

• Chemical Name: 5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione
• CAS No.: 103789-42-0
• Molecular Formula: C₂₂H₁₈N₂O₄S
• Molecular Weight: 406.462
• Mol file: 103789-42-0.mol

Synonyms:5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione

Chemical Property of 5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione

There total 9 articles about 5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

thiazoline-2,4-dione (2295-31-0) + 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzaldehyde (103788-59-6) → 5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione (103789-42-0)

Guidance literature:

With piperidine; In ethanol; for 9h; Heating;

DOI:10.1021/jm00092a012

Reference yield: 76.8%

piperidine (110-89-4) + thiazoline-2,4-dione (2295-31-0) + 4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzaldehyde (103788-59-6) → 5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione (103789-42-0)

Guidance literature:

In ethanol;

Reference yield:

4-fluorobenzonitrile (1194-02-1,143234-87-1) → 5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzylidene}-2,4-thiazolidinedione (103789-42-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 91 percent / NaH / tetrahydrofuran / 12 h / Ambient temperature

2: 65 percent / aq. HCOOH / Ra-Ni alloy / 3 h / 100 °C

3: 80 percent / piperidine / ethanol / 9 h / Heating

With piperidine; formic acid; sodium hydride; Ra-Ni alloy; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00092a012

upstream raw materials:

thiazoline-2,4-dione

4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzaldehyde

4-fluorobenzonitrile

N-benzoyl-L-aspartic acid β-methyl ester

Downstream raw materials:

5-{4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]benzyl}-2,4-thiazolidinedione