N-BENZOYL-L-ASPARTIC ACID-Beta-METHYL ESTER

Base Information

• Chemical Name: N-BENZOYL-L-ASPARTIC ACID-Beta-METHYL ESTER
• CAS No.: 39741-26-9
• Molecular Formula: C12H13NO5
• Molecular Weight: 251.23
• Hs Code.: 2922498590
• Mol file: 39741-26-9.mol

Synonyms:N-BENZOYL-L-ASPARTIC ACID-Beta-METHYL ESTER;N-Benzooyl-L-aspartic acid-B-methyl ester;N-Benzoyl-L-Aspartic Acid Methyl Ester;N-BENZOYL-ASPARTIC ACID-4-METHYL ESTER;N-BENZOY-L-ASPARTIC ACID-BETA-METHYL ESTER;N-BENZOOYL-L-ASPARTIC ACID--METHYL ESTER;N-Benzooyl-L-asparticacid-beta-methylester;N-Benzoyl-L-aspartic acid 4-methyl ester

Chemical Property of N-BENZOYL-L-ASPARTIC ACID-Beta-METHYL ESTER

Chemical Property:

• Boiling Point: 531.914 °C at 760 mmHg
• Flash Point: 275.492 °C
• PSA: 92.70000
• Density: 1.293 g/cm³
• LogP: 0.82360
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(S)-2-Benzamido-4-methoxy-4-oxobutanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-BENZOYL-L-ASPARTIC ACID-Beta-METHYL ESTER

There total 2 articles about N-BENZOYL-L-ASPARTIC ACID-Beta-METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(+)-β-methyl-L-aspartate hydrochloride (16856-13-6) + benzoyl chloride (98-88-4) → N-benzoyl-L-aspartic acid β-methyl ester (39741-26-9)

Guidance literature:

In dichloromethane; for 1h;

DOI:10.1021/jm00092a012

Reference yield: 16.0%

β-methyl L-aspartate (2177-62-0) + benzoyl chloride (98-88-4) → N-benzoyl-L-aspartic acid β-methyl ester (39741-26-9)

Guidance literature:

With sodium carbonate; In water; at 0 - 23 ℃;

DOI:10.1021/jo402828f

Reference yield: 78.0%

N-benzoyl-L-aspartic acid β-methyl ester (39741-26-9) + methyl (2S)-2-amino-3-hydroxypropanoate hydrochloride (5680-80-8) → Bz-Asp(β-OMe)-Ser-OMe

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide;

DOI:10.1021/ja00094a008

upstream raw materials:

(+)-β-methyl-L-aspartate hydrochloride

benzoyl chloride

β-methyl L-aspartate

Downstream raw materials:

(2S)-N-benzoyl-L-aspartic acid dimethyl ester

(Z)-methyl 3-(benzamido)acrylate

methyl (E)-3-benzamidoacrylate

methyl 3-benzamido-4-oxovalerate

Refernces

• 1、 Sohda,Mizuno,Momose,Ikeda,Fujita,Meguro. "Studies on antidiabetic agents. 11. Novel thiazolidinedione derivatives as potent hypoglycemic and hypolipidemic agents". . p. 2617 - 2626. Retrieved 2007/10/02.
• 2、 Meguro,Tawada,Sugiyama,Fujita,Kawamatsu. "Studies on antidiabetic agents. VII. Synthesis and hypoglycemic activity of 4-oxazoleacetic acid derivatives". . p. 2840 - 2851. Retrieved 2007/10/02.