7-benzyloxymethyl-3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione

Base Information

Chemical Name:7-benzyloxymethyl-3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione
CAS No.:756481-42-2
Molecular Formula:C₂₃H₂₃ClN₄O₄
Molecular Weight:454.913
Hs Code.:

Synonyms:7-benzyloxymethyl-3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione

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Chemical Property of 7-benzyloxymethyl-3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione

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Technology Process of 7-benzyloxymethyl-3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione

There total 6 articles about 7-benzyloxymethyl-3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3587-60-8
Benzyloxymethyl chloride

: 756481-19-3
3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione

: 756481-42-2
7-benzyloxymethyl-3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione

Guidance literature:: With tetra-(n-butyl)ammonium iodide; potassium carbonate; In N,N-dimethyl-formamide; at 45 ℃;
DOI:10.1021/jm049787k

Reference yield:

: 21260-49-1
N-methyl-N'-(p-methoxyphenyl)urea

: 756481-42-2
7-benzyloxymethyl-3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: 75 percent / N-chlorosuccinimide / acetonitrile / 0.67 h / 90 °C

2.1: acetic anhydride / 85 °C

2.2: 20 percent NaOH / 70 °C

3.1: aq. NaNO₂; acetic acid / 50 - 75 °C

4.1: aq. NH₄OH; Na₂S₂O₄ / 50 °C

5.1: ethanol / Heating

6.1: K₂CO₃; Bu₄NI / dimethylformamide / 45 °C

With ammonium hydroxide; N-chloro-succinimide; sodium dithionite; acetic anhydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid; sodium nitrite; In ethanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm049787k

Reference yield:

: 488706-01-0
N-(2-chloro-4-methoxyphenyl)-N'-methylurea

: 756481-42-2
7-benzyloxymethyl-3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic anhydride / 85 °C

1.2: 20 percent NaOH / 70 °C

2.1: aq. NaNO₂; acetic acid / 50 - 75 °C

3.1: aq. NH₄OH; Na₂S₂O₄ / 50 °C

4.1: ethanol / Heating

5.1: K₂CO₃; Bu₄NI / dimethylformamide / 45 °C

With ammonium hydroxide; sodium dithionite; acetic anhydride; tetra-(n-butyl)ammonium iodide; potassium carbonate; acetic acid; sodium nitrite; In ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm049787k