21260-49-1

Basic information

• Product Name: 1-(4-METHOXYPHENYL)-3-METHYLUREA
• Synonyms: 1-(4-METHOXYPHENYL)-3-METHYLUREA;1-(P-ANISYL)-3-METHYLUREA
• CAS NO: 21260-49-1
• Molecular Formula: C₉H₁₂N₂O₂
• Molecular Weight: 180.2038
• Mol File: 21260-49-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 278.8°Cat760mmHg
• Flash Point: 122.4°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 0.00417mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: 1-(4-METHOXYPHENYL)-3-METHYLUREA(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXYPHENYL)-3-METHYLUREA(21260-49-1)
• EPA Substance Registry System: 1-(4-METHOXYPHENYL)-3-METHYLUREA(21260-49-1)

Safety Data

• Hazardous Substances Data: 21260-49-1(Hazardous Substances Data)

Usage

General Description

1-(4-methoxyphenyl)-3-methylurea is a chemical compound with the molecular formula C10H13N3O2. It is a urea derivative with a methyl group and a 4-methoxyphenyl group attached to the nitrogen atom. 1-(4-METHOXYPHENYL)-3-METHYLUREA is a white crystalline solid that is sparingly soluble in water. 1-(4-methoxyphenyl)-3-methylurea is used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It has potential applications in the field of medicinal chemistry and drug discovery. Additionally, it may have other uses such as in the synthesis of dyes and other specialty chemicals.

InChI:InChI=1/C9H12N2O2/c1-10-9(12)11-7-3-5-8(13-2)6-4-7/h3-6H,1-2H3,(H2,10,11,12)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 624-83-9 methyl isocyanate 
• 5416-93-3 4-Methoxyphenyl isocyanate 
• 372-09-8 cyanoacetic acid 
• 696-62-8 para-iodoanisole 
• 768-60-5 4-methoxyphenylacetylen 

Downstream Products

• 488706-01-0 N-(2-chloro-4-methoxyphenyl)-N'-methylurea 
• 110396-81-1 3-isopropyl-1-(2-nitro-4-tolyl)urea 
• 76266-50-7 1,1,3-Trimethyl-5-(4-methoxyphenyl)biuret 
• 37830-82-3 C₁₁H₁₅N₃O₃ 
• 76562-53-3 [3-(4-Methoxy-phenyl)-1-methyl-2,6-dioxo-2,3,6,9-tetrahydro-1H-purin-8-yl]-carbamic acid ethyl ester 
• 76562-52-2 [3-(4-Methoxy-phenyl)-1-methyl-2,6-dioxo-2,3,6,9-tetrahydro-1H-purin-8-yl]-carbamic acid methyl ester 
• 76562-57-7 1-p-Methoxyphenyl-3-methyl-5-nitroso-6-aminouracil 
• 76562-58-8 1-p-Methoxyphenyl-3-methyl-5,6-diaminouracil 
• 756481-42-2 7-benzyloxymethyl-3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 756481-44-4 7-benzyloxymethyl-3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-1,2,3,7-tetrahydro-purin-6-one 
• 756481-43-3 3-benzyloxymethyl-5-(2-chloro-4-methoxy-phenylamino)-2-ethyl-3H-imidazole-4-carboxylic acid methylamide 
• 756481-19-3 3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-3,7-dihydro-purine-2,6-dione 
• 756481-45-5 3-(2-chloro-4-methoxy-phenyl)-8-ethyl-1-methyl-1,2,3,7-tetrahydro-purin-6-one 
• 756481-23-9 5,6-diamino-1-(2-chloro-4-methoxy-phenyl)-3-methyl-1H-pyrimidine-2,4-dione 

Relevant articles and documents

Splitting a Substrate into Three Parts: Gold-Catalyzed Nitrogenation of Alkynes by C-C and C≡C Bond Cleavage

A gold-catalyzed nitrogenation of alkynes for the synthesis of carbamides and amino tetrazoles through C-C and C≡C bond cleavages is described. A diverse set of functionalized carbamide and amino tetrazole derivatives were selectively constructed under mild conditions. The chemoselectivity can be easily switched by the selection of the acid additives. The reaction is characterized by its broad substrate scope, direct construction of high value products, easy operation under air, and mild conditions at room temperature. This chemistry provides a way to transform alkynes by splitting the substrate into three parts.

PREPARATION AND PROPERTIES OF 3-ALKYL-i-ARYLNITROSOUREAS AND RELATED COMPOUNDS

Nitrosation of 3-alkyl-1-arylureas was investigated with sodium nitrite in 99percent formic acid or with isoamyl nitrite in chloroform.The preparation of 3-alkyl-1-aryl-1-nitrosoureas was effectively performed by using isoamyl nitrite in the absence of acids, since the 1-nitrosoureas were isomerized to the 3-nitroso isomers by acids.The carbon-13 nuclear magnetic resonance and infrared spectral properties of the products were examined and their structural features are discussed.It was found that 3-alkyl-1-aryl-1-nitrosoureas decomposed to form alkyl isocyanates and 3-alkyl-1-(2-nitroaryl)ureas in carbon tetrachloride. 1,3-Rearrangement and transnitrosation also took place in this solvent.Keywords - 3-alkyl-1-arylnitrosourea; 3,3-diethyl-1-tolyl-1-nitrosourea; N-nitrosourea; nitrosation; 1,3-rearrangement; isomerization; transnitrosation; nitration