3-Acetyl-2(3H)-oxazolone

Base Information

• Chemical Name: 3-Acetyl-2(3H)-oxazolone
• CAS No.: 60759-49-1
• Molecular Formula: C5H5NO3
• Molecular Weight: 127.1
• Hs Code.: 2934999090
• Mol file: 60759-49-1.mol

Synonyms:3-Acetyloxazolin-2-one;N-Acetyl-1,3-oxazol-2-one;3-Acetyl-2-oxazolone;3-Acetyl-4-oxazolin-2-one;

Chemical Property of 3-Acetyl-2(3H)-oxazolone

Chemical Property:

• Vapor Pressure: 0.155mmHg at 25°C
• Melting Point: 36-38 °C
• Refractive Index: 1.52
• Boiling Point: 214.6 °C at 760 mmHg
• PKA: -3.04±0.20(Predicted)
• Flash Point: 107.2 °C
• PSA: 52.21000
• Density: 1.383 g/cm³
• LogP: 0.10140

Purity/Quality:

99%, ^*data from raw suppliers

3-Acetyloxazolin-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Acetyl-2(3H)-oxazolone

There total 8 articles about 3-Acetyl-2(3H)-oxazolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

4-methoxy-1,3-oxazolidin-2-one (14441-94-2) + acetic anhydride (108-24-7) → 3'-Acetyl-4',5'-dihydro-3'H-[3,4']bioxazolyl-2,2'-dione (120224-29-5) + N-acetyl-1,3-oxazol-2-one (60759-49-1)

Guidance literature:

In toluene; for 0.5h; Heating;

Reference yield: 58.0%

N-acetyl-4,5-dichloro-2-oxazolidinone → N-acetyl-1,3-oxazol-2-one (60759-49-1)

Guidance literature:

With zinc; In acetic acid;

DOI:10.1055/s-2007-977415

Reference yield: 58.0%

C5H5Cl2NO3 → N-acetyl-1,3-oxazol-2-one (60759-49-1)

Guidance literature:

With acetic acid; zinc; Inert atmosphere;

DOI:10.1016/j.tet.2009.08.066

upstream raw materials:

3-acetyl-1,3-oxazolidin-2-one

4-methoxy-1,3-oxazolidin-2-one

acetic anhydride

Diphenyl 2-oxo-3-oxazolinylphosphonate

Downstream raw materials:

4-acetyl-2-oxa-4-aza-bicyclo[3.2.0]heptan-3-one

4-acetyl-2-oxa-4-aza-bicyclo[3.2.0]hept-6-en-3-one

Acetanilid

4-oxazolin-2-one

Refernces

• 1、 Gaenzler, Faith Corbo,Guo, Chen (Lisa),Zhang, Yun-Wei,Azab, Mohammad E.,Salem, Mounir A.I.,Fan, Dong Ping,Smith, Michael B.. "2-Dienylphenacyloxazolones and an intramolecular Diels-Alder approach to the A-B-C ring system of phenanthridone alkaloids". scheme or table. p. 8781 - 8785. Retrieved 2009/12/26.
• 2、 Tavernier, Dirk,Damme, Sabine van,Ricquier, Patrick,Anteunis, Marc J. O.. "A CONVENIENT PREPARATION OF 3H-1,3-OXAZOL-2-ONE AND ITS N-FORMYL DERIVATIVE". . p. 859 - 866. Retrieved 2007/10/02.