3,3,3-Trifluoropropanehydrazide

Base Information

• Chemical Name: 3,3,3-Trifluoropropanehydrazide
• CAS No.: 934171-99-0
• Molecular Formula: C₃H₅F₃N₂O
• Molecular Weight: 142.081
• European Community (EC) Number: 822-207-2
• Mol file: 934171-99-0.mol

Synonyms:3,3,3-trifluoropropanehydrazide;934171-99-0;3,3,3-Trifluoro-propionic acid hydrazide;SCHEMBL2038041;AKOS000139832;DB-330861;CS-0250288;EN300-50335;F74598

Chemical Property of 3,3,3-Trifluoropropanehydrazide

Chemical Property:

• Boiling Point: 207.7±40.0 °C(Predicted)
• Density: 1.365±0.06 g/cm3(Predicted)
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 142.03539727
• Heavy Atom Count: 9
• Complexity: 110

Purity/Quality:

97% ^*data from raw suppliers

3,3,3-trifluoropropanehydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C(C(=O)NN)C(F)(F)F

Technology Process of 3,3,3-Trifluoropropanehydrazide

There total 3 articles about 3,3,3-Trifluoropropanehydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

methyl 3,3,3-trifluoropropionate (18830-44-9) → 3,3,3-trifluoropropanehydrazide (934171-99-0)

Guidance literature:

With hydrazine hydrate; In methanol; at 0 - 20 ℃; for 25h;

Reference yield: 58.0%

→ 3,3,3-trifluoropropanehydrazide (934171-99-0)

Guidance literature:

Reference yield:

ethyl 3,3,3-trifluoropropanoate (352-23-8) → 3,3,3-trifluoropropanehydrazide (934171-99-0)

Guidance literature:

With hydrazine hydrate; for 1h; Reflux;

upstream raw materials:

methyl 3,3,3-trifluoropropionate

ethyl 3,3,3-trifluoropropanoate

Downstream raw materials:

tert-butyl (1-(4-(8-phenyl-1-(2,2,2-trifluoroethyl)-4H-pyrido[2,3-b][1,2,4]triazolo[4,3-d][1,4]oxazin-7-yl)phenyl)cyclobutyl)carbamate

(2R,5S)-6-(benzyloxy)-7-oxo-N’-(3,3,3-trifluoropropanoyl)-1,6-diazabicyclo[3.2.1]octane-2-carbohydrazide