352-23-8Relevant articles and documents
Synthesis of ethyl 3,3,3-trifluoropropionate from 2-bromo-3,3,3-trifluoropropene Dedicated to Dr. Teruo Umemoto on the occasion of his receipt of the ACS Award for Creative Work in Fluorine Chemistry 2014.
Inoue, Munenori,Shiosaki, Masahiro,Muramaru, Hajime
, p. 135 - 138 (2014)
A facile synthesis of ethyl 3,3,3-trifluoropropionate is described. Commercially available 2-bromo-3,3,3-trifluoropropene was used as a starting material, which was allowed to react with bromine to produce 2,2,3-tribromo-1,1,1-trifluoropropane. The resulting tribromide was treated with 3 equiv. of potassium ethoxide, giving rise to ethyl 3,3,3-trifluoropropionate in 60% overall yield in 2 steps. The reaction proceeded via an alkoxide-induced tandem reaction mechanism.
Method for preparing 3,3,3-trifluoro ethyl propionate
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Paragraph 0004; 0012; 0013; 0014; 0015; 0016; 0017, (2016/10/10)
The invention provides a method for preparing 3,3,3-trifluoro ethyl propionate. According to the method, 3,3,3-trifluoro ethyl propionate is synthesized from 3,3,3-trifluoro propionic acid and ethanol, which serve as raw materials, under the catalysis of a tungsten-containing compound. The method is environment-friendly and is free of pollution caused by waste gases, waste water and waste residues, the catalytic selectivity is high, and the catalyst is easy to separate and can be recovered, so that the method has a good industrial application prospect.
Synthesis of 3,3,3-trifluoroethyl isocyanate, carbamate and ureas. Anticancer activity evaluation of N-(3,3,3-trifluoroethyl)-N′-substituted ureas
Luzina, Elena L.,Popov, Anatoliy V.
, p. 82 - 88 (2015/06/25)
A new method is described for producing 3,3,3-trifluoroethyl isocyanate from perfluoroisobutene (PFIB). Isocyanate was used for synthesis of carbamates and ureas. A series of trifluoroethyl-substituted ureas has been tested in the National Cancer Institute (NCI, Bethesda, USA) by the NCI-60 DTP Human Tumor Cell Line Screening Program at a single high dose (10-5 M). The moderate anticancer activity was shown against some types of cancer on the individual human cell lines for leukemia, non-small cell lung cancer and renal cancer.