352-23-8Relevant academic research and scientific papers
Synthesis of ethyl 3,3,3-trifluoropropionate from 2-bromo-3,3,3-trifluoropropene Dedicated to Dr. Teruo Umemoto on the occasion of his receipt of the ACS Award for Creative Work in Fluorine Chemistry 2014.
Inoue, Munenori,Shiosaki, Masahiro,Muramaru, Hajime
, p. 135 - 138 (2014)
A facile synthesis of ethyl 3,3,3-trifluoropropionate is described. Commercially available 2-bromo-3,3,3-trifluoropropene was used as a starting material, which was allowed to react with bromine to produce 2,2,3-tribromo-1,1,1-trifluoropropane. The resulting tribromide was treated with 3 equiv. of potassium ethoxide, giving rise to ethyl 3,3,3-trifluoropropionate in 60% overall yield in 2 steps. The reaction proceeded via an alkoxide-induced tandem reaction mechanism.
Method for preparing 3,3,3-trifluoro ethyl propionate
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Paragraph 0004; 0012; 0013; 0014; 0015; 0016; 0017, (2016/10/10)
The invention provides a method for preparing 3,3,3-trifluoro ethyl propionate. According to the method, 3,3,3-trifluoro ethyl propionate is synthesized from 3,3,3-trifluoro propionic acid and ethanol, which serve as raw materials, under the catalysis of a tungsten-containing compound. The method is environment-friendly and is free of pollution caused by waste gases, waste water and waste residues, the catalytic selectivity is high, and the catalyst is easy to separate and can be recovered, so that the method has a good industrial application prospect.
Method for producing 3, 3, 3 - [...] (by machine translation)
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Paragraph 0061; 0062, (2019/10/19)
PROBLEM TO BE SOLVED: To provide a simple, efficient and inexpensive method capable of manufacturing a 3,3,3-trifluoro propionyl compound useful as a pharmaceutical and agricultural synthetic intermediate in an industrial scale.SOLUTION: There is provided a method of manufacturing a compound represented by the formula [1] by reacting a compound represented by the formula [2] with a polar compound after hydrolysis with using sulfuric acid. In the formula [1], X is Cl, OH, ORor NRR, Ris a Cto Calkyl group, a Cto Chalogenated alkyl group or phenyl group, Rand Rmay be same or different and are each independently a hydrogen, a Cto Calkyl group, a Cto Chalogenated alkyl group or phenyl group and each may together form a ring structure.
METHOD FOR PROCESSING FLUORIC ACID
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, (2015/09/22)
The present invention relates to a method for processing an aqueous solution containing a salt of an organic compound including at least one acid function and at least one fluorine atom, or fluoric acid, by reaction between said salt and at least one Bronsted acid and an alcohol in the presence of an organic solvent solubilizing the resulting product, wherein said organic solvent consists of at least one dual-phase liquid/liquid reaction medium with the aqueous solution.
Synthesis of 3,3,3-trifluoroethyl isocyanate, carbamate and ureas. Anticancer activity evaluation of N-(3,3,3-trifluoroethyl)-N′-substituted ureas
Luzina, Elena L.,Popov, Anatoliy V.
, p. 82 - 88 (2015/06/25)
A new method is described for producing 3,3,3-trifluoroethyl isocyanate from perfluoroisobutene (PFIB). Isocyanate was used for synthesis of carbamates and ureas. A series of trifluoroethyl-substituted ureas has been tested in the National Cancer Institute (NCI, Bethesda, USA) by the NCI-60 DTP Human Tumor Cell Line Screening Program at a single high dose (10-5 M). The moderate anticancer activity was shown against some types of cancer on the individual human cell lines for leukemia, non-small cell lung cancer and renal cancer.
Bis-exo-2-norbornylboron triflate for stereospecific enolization of 3,3,3-trifluoropropionates
Ramachandran, P. Veeraraghavan,Parthasarathy, Gowrisankar,Gagare, Pravin D.
supporting information; experimental part, p. 4474 - 4477 (2010/12/24)
The first boron-mediated enolization - aldolization of 3,3,3- trifluoropropionates has been reported. The preparation and application of bis-exo-bicyclo[2.2.1]heptan-2-ylboron triflate as a superior reagent for diastereospecific enolization has also been described.
SELECTIVELY REACTING OLEFINS HAVING A TERMINAL CF2 GROUP IN A MIXTURE
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Example 15, (2008/06/13)
A process is disclosed for reducing the mole ratio of (1) compounds of the formula Y1Y2C=CF2 wherein Y1 and Y2 are each independently H, F, CI, Br, C1-C6 alkyl or C1-C6 haloalkyl containing no more than 3 chlorine substituents, 2 bromine substituents and 1 iodo substituent to (2) saturated compounds of the formula CdHeFfCIgBrhIk wherein d is an integer from 1 to 10, and e+f+g+h+k is equal to 2d+2, provided that g is 0, 1, 2 or 3, h is 0, 1 or 2 and k is 0 or 1 and/or unsaturated compounds of the formula Y3Y4C=CY5Y6, wherein Y3, Y5 and Y6 are each independently H, F, CI Br, C1-C6 alkyl or C1-C6 haloalkyl containing no more than 3 chlorine substituents, 2 bromine substituents and 1 iodo substituent, provided that Y5 and Y6 are not both F, and Y4 is C1-C6 alkyl or C1-C6 haloalkyl containing no more than 3 chlorine substituents, 2 bromine substituents and 1 iodo substituent, in a mixture. The process involves contacting the mixture with at least one selective removal agent selected from the group consisting of SO3 and RSO3H, wherein R is selected from the group consisting of F, CI, OH, C1-C8 alkyl, C1-C8 fluoroalkyl, and C1-C8 fluoroalkoxyalkyl containing no more than two ether oxygens to selectively react the formula Y1Y2C=CF2 compounds.
SUBSTITUTED AMINO HETEROCYCLES AS VR-1 ANTAGONISTS FOR TREATING PAIN
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Page 81, (2010/02/08)
The present invention provides compounds of formula I: in which: one of T1and T4 is N and the other is C; T2 and T3 are independently N or C(CH2)nR2; X, Y and Z are independently N or C(CH2)nR3; R1 is Ar1 or R1 is C1-6alkyl optionally substituted with one or two groups Ar1; Ar1 is an optionally substituted cyclohexyl, piperidinyl, piperazinyl, morpholinyl, adamantyl, phenyl, naphthyl, a six-membered heteroaromatic ring containing one, two or three nitrogen atoms, a five-membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one O or S atom being present, or a nine- or ten-membered bicyclic heteroaromatic ring in which phenyl or a six-membered heteroaromatic ring as defined above is fused to a six-or five-membered heteroaromatic ring as defined above; Ar is an optionally substituted phenyl, a six-membered heteroaromatic ring containing one, two or three nitrogen atoms or a five-membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, Ar being optionally substituted by one, two or three groups chosen from halogen, CF3, OCF3, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, nitro, cyano, isonitrile, hydroxy, C1-6alkoxy, C1-6alkylthio, -NR6R7, -CONR6R7, -COH, CO2H, C1-6alkoxycarbonyl, haloC1-6alkyl, hydroxyC1-6alkyl, aminoC1-6alkyl, C1-6alkylcarbonyl and a five-membered heteroaromatic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, optionally substituted by C1-6alkyl, halogen, amino, hydroxy or cyano; or a pharmaceutically acceptable salt thereof as a VR-1 ligand; pharmaceutical compositions comprising it; its use in therapy; use of it in the manufacture of a medicament to treat pain; and methods of treating subjects suffering from pain.
METHYL CHLORODIFLUOROACETATE. A CONVENIENT TRIFLUOROMETHYLATING AGENT
Su, De-Bao,Duan, Jian-Xing,Chen, Quing-Yun
, p. 7689 - 7690 (2007/10/02)
Treatment of methyl chlorodifluoroacetate with organic halides in the presence of KF and CuI at 100-120 deg C for 7-8 h in DMF gave the corresponding trifluoromethylated derivatives in moderate to high yields.
