bis-O,O'-tert-butyldimethylsilyl-4-[1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranos-1-yl]catechol

Base Information

Chemical Name:bis-O,O'-tert-butyldimethylsilyl-4-[1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranos-1-yl]catechol
CAS No.:307003-28-7
Molecular Formula:C₄₄H₆₀O₇Si₂
Molecular Weight:757.127
Hs Code.:

Synonyms:bis-O,O'-tert-butyldimethylsilyl-4-[1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranos-1-yl]catechol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of bis-O,O'-tert-butyldimethylsilyl-4-[1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranos-1-yl]catechol

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Technology Process of bis-O,O'-tert-butyldimethylsilyl-4-[1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranos-1-yl]catechol

There total 1 articles about bis-O,O'-tert-butyldimethylsilyl-4-[1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranos-1-yl]catechol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 307003-27-6
O,O'-bis(tert-butyldimethylsilyl)-4-(1,2-dideoxy-β-D-ribofuranos-1-yl)catechol

: 307003-28-7
bis-O,O'-tert-butyldimethylsilyl-4-[1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranos-1-yl]catechol

Guidance literature:: With pyridine; at 20 ℃; for 3h;
DOI:10.1248/cpb.48.1745

Reference yield: 92.0%

: 307003-28-7
bis-O,O'-tert-butyldimethylsilyl-4-[1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranos-1-yl]catechol

: 316124-02-4
4-[1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranos-1-yl]catechol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.166667h;
DOI:10.1248/cpb.48.1745

Reference yield:

: 307003-28-7
bis-O,O'-tert-butyldimethylsilyl-4-[1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranos-1-yl]catechol

: 316124-03-5
di-O,O'-acetyl-4-[1,2-dideoxy-5-O-(4,4'-dimethoxytrityl)-β-D-ribofuranos-1-yl]catechol

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / n-Bu₄NF / tetrahydrofuran / 0.17 h

2: 67 percent / t-BuOK / tetrahydrofuran / 1 h

With potassium tert-butylate; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1248/cpb.48.1745