tert-butyl (3R)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-(4-methoxyphenyl)-4-oxobutanoate

Base Information

Chemical Name:tert-butyl (3R)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-(4-methoxyphenyl)-4-oxobutanoate
CAS No.:873326-19-3
Molecular Formula:C₂₅H₂₉NO₆
Molecular Weight:439.508
Hs Code.:

Synonyms:tert-butyl (3R)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-(4-methoxyphenyl)-4-oxobutanoate

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Chemical Property of tert-butyl (3R)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-(4-methoxyphenyl)-4-oxobutanoate

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Technology Process of tert-butyl (3R)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-(4-methoxyphenyl)-4-oxobutanoate

There total 1 articles about tert-butyl (3R)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-(4-methoxyphenyl)-4-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 143590-12-9
(R)-4-benzyl-3-(2-(4-methoxyphenyl)acetyl)oxazolidin-2-one

: 873326-19-3
tert-butyl (3R)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-(4-methoxyphenyl)-4-oxobutanoate

Guidance literature:: (R)-4-benzyl-3-(2-(4-methoxyphenyl)acetyl)oxazolidin-2-one; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 2.5h;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; at -78 ℃; for 3h;
DOI:10.1002/chem.200500319

Reference yield: 78.0%

: 873326-19-3
tert-butyl (3R)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-(4-methoxyphenyl)-4-oxobutanoate

: 873326-20-6
(2R)-4-tert-butoxy-2-(4-methoxyphenyl)-4-oxobutanoic acid

Guidance literature:: With lithium hydroxide; dihydrogen peroxide; In tetrahydrofuran; at 0 ℃; for 5h;
DOI:10.1002/chem.200500319

Reference yield:

: 873326-19-3
tert-butyl (3R)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-(4-methoxyphenyl)-4-oxobutanoate

: 873326-21-7
tert-butyl (3R)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(4-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 78 percent / aq. H₂O₂; LiOH / tetrahydrofuran / 5 h / 0 °C

2.1: (PhO)2P(O)N₃; Et₃N / toluene / 0.5 h / 23 °C

2.2: toluene / 4 h / Heating

3.1: 0.61 g / toluene / 3 h / Heating

With lithium hydroxide; diphenyl phosphoryl azide; dihydrogen peroxide; triethylamine; In tetrahydrofuran; toluene; 2.2: Curtius rearrangement;
DOI:10.1002/chem.200500319