tert-butyl (3R)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(4-methoxyphenyl)propanoate

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Chemical Name:tert-butyl (3R)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(4-methoxyphenyl)propanoate
CAS No.:873326-21-7
Molecular Formula:C₂₉H₃₁NO₅
Molecular Weight:473.569
Hs Code.:

Synonyms:tert-butyl (3R)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(4-methoxyphenyl)propanoate

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Chemical Property of tert-butyl (3R)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(4-methoxyphenyl)propanoate

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Technology Process of tert-butyl (3R)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(4-methoxyphenyl)propanoate

There total 5 articles about tert-butyl (3R)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(4-methoxyphenyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873326-20-6
(2R)-4-tert-butoxy-2-(4-methoxyphenyl)-4-oxobutanoic acid

: 873326-21-7
tert-butyl (3R)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(4-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (PhO)2P(O)N₃; Et₃N / toluene / 0.5 h / 23 °C

1.2: toluene / 4 h / Heating

2.1: 0.61 g / toluene / 3 h / Heating

With diphenyl phosphoryl azide; triethylamine; In toluene; 1.2: Curtius rearrangement;
DOI:10.1002/chem.200500319

Reference yield:

: 873326-19-3
tert-butyl (3R)-4-[(4R)-4-benzyl-2-oxo-1,3-oxazolidin-3-yl]-3-(4-methoxyphenyl)-4-oxobutanoate

: 873326-21-7
tert-butyl (3R)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(4-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 78 percent / aq. H₂O₂; LiOH / tetrahydrofuran / 5 h / 0 °C

2.1: (PhO)2P(O)N₃; Et₃N / toluene / 0.5 h / 23 °C

2.2: toluene / 4 h / Heating

3.1: 0.61 g / toluene / 3 h / Heating

With lithium hydroxide; diphenyl phosphoryl azide; dihydrogen peroxide; triethylamine; In tetrahydrofuran; toluene; 2.2: Curtius rearrangement;
DOI:10.1002/chem.200500319

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 873326-21-7
tert-butyl (3R)-3-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-3-(4-methoxyphenyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaHMDS / tetrahydrofuran / 2.5 h / -78 °C

1.2: 71 percent / tetrahydrofuran / 3 h / -78 °C

2.1: 78 percent / aq. H₂O₂; LiOH / tetrahydrofuran / 5 h / 0 °C

3.1: (PhO)2P(O)N₃; Et₃N / toluene / 0.5 h / 23 °C

3.2: toluene / 4 h / Heating

4.1: 0.61 g / toluene / 3 h / Heating

With lithium hydroxide; diphenyl phosphoryl azide; dihydrogen peroxide; sodium hexamethyldisilazane; triethylamine; In tetrahydrofuran; toluene; 3.2: Curtius rearrangement;
DOI:10.1002/chem.200500319