(S)-1-((2S,7R)-7-((S)-1-(benzyloxy)propyl)-2,3,6,7-tetrahydrooxepin-2-yl)propane-1,3-diol

Base Information

Chemical Name:(S)-1-((2S,7R)-7-((S)-1-(benzyloxy)propyl)-2,3,6,7-tetrahydrooxepin-2-yl)propane-1,3-diol
CAS No.:1582741-08-9
Molecular Formula:C₁₉H₂₈O₄
Molecular Weight:320.429
Hs Code.:

Synonyms:(S)-1-((2S,7R)-7-((S)-1-(benzyloxy)propyl)-2,3,6,7-tetrahydrooxepin-2-yl)propane-1,3-diol

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Chemical Property of (S)-1-((2S,7R)-7-((S)-1-(benzyloxy)propyl)-2,3,6,7-tetrahydrooxepin-2-yl)propane-1,3-diol

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Technology Process of (S)-1-((2S,7R)-7-((S)-1-(benzyloxy)propyl)-2,3,6,7-tetrahydrooxepin-2-yl)propane-1,3-diol

There total 6 articles about (S)-1-((2S,7R)-7-((S)-1-(benzyloxy)propyl)-2,3,6,7-tetrahydrooxepin-2-yl)propane-1,3-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1582741-04-5
C₁₉H₂₆O₄

: 1582741-08-9
(S)-1-((2S,7R)-7-((S)-1-(benzyloxy)propyl)-2,3,6,7-tetrahydrooxepin-2-yl)propane-1,3-diol

Guidance literature:: With Red-Al; In tetrahydrofuran; toluene; at 0 ℃; for 3h; Inert atmosphere;
DOI:10.1039/c4cc00389f

Reference yield:

: 100-39-0
benzyl bromide

: 1582741-08-9
(S)-1-((2S,7R)-7-((S)-1-(benzyloxy)propyl)-2,3,6,7-tetrahydrooxepin-2-yl)propane-1,3-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / 0 - 70 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere

4.1: diethyl (2R,3R)-tartrate; titanium(IV) isopropylate / dichloromethane / 0.5 h / -20 °C / Molecular sieve

4.2: 8 h / 20 °C / Molecular sieve

5.1: Red-Al^? / tetrahydrofuran; toluene / 3 h / 0 °C / Inert atmosphere

With titanium(IV) isopropylate; lithium aluminium tetrahydride; n-butyllithium; diethyl (2R,3R)-tartrate; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; hexane; dichloromethane; toluene; mineral oil;
DOI:10.1039/c4cc00389f

Reference yield:

: 1582740-92-8
(S)-1-((2R,7R)-7-ethynyl-2,3,6,7-tetrahydrooxepin-2-yl)propan-1-ol

: 1582741-08-9
(S)-1-((2S,7R)-7-((S)-1-(benzyloxy)propyl)-2,3,6,7-tetrahydrooxepin-2-yl)propane-1,3-diol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride; tetra-(n-butyl)ammonium iodide / tetrahydrofuran; mineral oil / 0 - 70 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -20 °C / Inert atmosphere

2.2: 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Inert atmosphere

4.1: diethyl (2R,3R)-tartrate; titanium(IV) isopropylate / dichloromethane / 0.5 h / -20 °C / Molecular sieve

4.2: 8 h / 20 °C / Molecular sieve

5.1: Red-Al^? / tetrahydrofuran; toluene / 3 h / 0 °C / Inert atmosphere

With titanium(IV) isopropylate; lithium aluminium tetrahydride; n-butyllithium; diethyl (2R,3R)-tartrate; tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; hexane; dichloromethane; toluene; mineral oil;
DOI:10.1039/c4cc00389f