tert-butyl rac-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]-1-piperidine carbamate

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Chemical Name:tert-butyl rac-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]-1-piperidine carbamate
CAS No.:1073136-04-5
Molecular Formula:C₂₂H₂₄BrN₃O₄
Molecular Weight:474.354
Hs Code.:

Synonyms:tert-butyl rac-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]-1-piperidine carbamate

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Chemical Property of tert-butyl rac-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]-1-piperidine carbamate

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Technology Process of tert-butyl rac-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]-1-piperidine carbamate

There total 5 articles about tert-butyl rac-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]-1-piperidine carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.9%

: 1073135-81-5
5-bromo-4-chloro-6-phenylfuro[2,3-d]pyrimidine

: 85275-45-2
N-tert-butoxycarbonyl-3-piperidinol

: 1073136-04-5
tert-butyl rac-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]-1-piperidine carbamate

Guidance literature:: 5-bromo-4-chloro-6-phenylfuro[2,3-d]pyrimidine; N-tert-butoxycarbonyl-3-piperidinol; With tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; In 1,2-dimethoxyethane; water; toluene; at 70 ℃; for 1h;

With hydrogenchloride; In 1,2-dimethoxyethane; water; toluene; pH=7;

Reference yield:

: 70-11-1
α-bromoacetophenone

: 1073136-04-5
tert-butyl rac-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]-1-piperidine carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: diethylamine / N,N-dimethyl-formamide / 20 °C

2.1: 1.5 h / 210 °C

3.1: N-Bromosuccinimide / tetrachloromethane / Reflux

4.1: hydrogenchloride; isopentyl nitrite / 1,4-dioxane; chloroform / Reflux

5.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / toluene; 1,2-dimethoxyethane; water / 1 h / 70 °C

5.2: pH 7

With hydrogenchloride; N-Bromosuccinimide; tetra(n-butyl)ammonium hydrogensulfate; diethylamine; sodium hydroxide; isopentyl nitrite; In 1,4-dioxane; tetrachloromethane; 1,2-dimethoxyethane; chloroform; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 14742-32-6
2-amino-5-phenylfuran-3-carbonitrile

: 1073136-04-5
tert-butyl rac-3-[(5-bromo-6-phenylfuro[2,3-d]pyrimidin-4-yl)oxy]-1-piperidine carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1.5 h / 210 °C

2.1: N-Bromosuccinimide / tetrachloromethane / Reflux

3.1: hydrogenchloride; isopentyl nitrite / 1,4-dioxane; chloroform / Reflux

4.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / toluene; 1,2-dimethoxyethane; water / 1 h / 70 °C

4.2: pH 7

With hydrogenchloride; N-Bromosuccinimide; tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide; isopentyl nitrite; In 1,4-dioxane; tetrachloromethane; 1,2-dimethoxyethane; chloroform; water; toluene;