1-[(2R,3S,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-mercapto-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,3S,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-mercapto-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione
CAS No.:199528-81-9
Molecular Formula:C₃₆H₄₄N₂O₇SSi
Molecular Weight:676.906
Hs Code.:

1-[(2R,3S,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-mercapto-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Synonyms:1-[(2R,3S,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-mercapto-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[(2R,3S,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-mercapto-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

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Technology Process of 1-[(2R,3S,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-mercapto-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

There total 11 articles about 1-[(2R,3S,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-mercapto-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 199528-80-8
1-[(2R,3S,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-(pyridin-2-yldisulfanyl)-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

: 199528-81-9
1-[(2R,3S,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-mercapto-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: With DL-dithiothreitol; In tetrahydrofuran; Yield given;
DOI:10.1080/07328319708006225

Reference yield:

: 75096-60-5
1,2-O-isopropylidene-5-O-(4-toluoyl)-D-xylofuranose

: 199528-81-9
1-[(2R,3S,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-mercapto-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 10 steps

1: DMAP / CH₂Cl₂ / Ambient temperature

2: dimethylformamide / 5 h / 80 °C

3: HCOOH / 1 h / 50 °C

4: pyridine

5: 2.) TMSTf / 2.) MeCN

6: MeONa / methanol

8: 91 percent / pyridine, DMAP / 10 h

9: imidazole / pyridine / 12 h / Ambient temperature

10: DTT / tetrahydrofuran

With pyridine; 1H-imidazole; dmap; formic acid; DL-dithiothreitol; TMSTf; sodium methylate; In tetrahydrofuran; pyridine; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1080/07328319708006225

Reference yield:

: 75096-61-6
1,2-O-isopropylidene-5-O-(4-methylbenzoyl)-3-O-trifluoromethanesulfonyl-α-D-xylofuranose

: 199528-81-9
1-[(2R,3S,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-mercapto-tetrahydro-furan-2-yl]-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 9 steps

1: dimethylformamide / 5 h / 80 °C

2: HCOOH / 1 h / 50 °C

3: pyridine

4: 2.) TMSTf / 2.) MeCN

5: MeONa / methanol

7: 91 percent / pyridine, DMAP / 10 h

8: imidazole / pyridine / 12 h / Ambient temperature

9: DTT / tetrahydrofuran

With pyridine; 1H-imidazole; dmap; formic acid; DL-dithiothreitol; TMSTf; sodium methylate; In tetrahydrofuran; pyridine; methanol; N,N-dimethyl-formamide;
DOI:10.1080/07328319708006225