(S)-methyl 3-(4-(benzyloxy)-3-iodophenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

Base Information

Chemical Name:(S)-methyl 3-(4-(benzyloxy)-3-iodophenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate
CAS No.:1364705-39-4
Molecular Formula:C₂₅H₃₁IN₂O₆
Molecular Weight:582.435
Hs Code.:

Synonyms:(S)-methyl 3-(4-(benzyloxy)-3-iodophenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

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Chemical Property of (S)-methyl 3-(4-(benzyloxy)-3-iodophenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

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Technology Process of (S)-methyl 3-(4-(benzyloxy)-3-iodophenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

There total 9 articles about (S)-methyl 3-(4-(benzyloxy)-3-iodophenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 15761-38-3
L-N-Boc-Ala

: 100-39-0
benzyl bromide

: 79677-58-0,122908-62-7
2-amino-3-(3-iodo-4-hydroxyphenyl)propionic acid methyl ester hydrochloride

: 1364705-39-4
(S)-methyl 3-(4-(benzyloxy)-3-iodophenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

Guidance literature:: L-N-Boc-Ala; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at -5 ℃; for 1h; Inert atmosphere;

2-amino-3-(3-iodo-4-hydroxyphenyl)propionic acid methyl ester hydrochloride; With 4-methyl-morpholine; In dichloromethane; at 0 ℃; for 2h; Inert atmosphere;

benzyl bromide; With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 55 ℃; for 2h; Inert atmosphere;
DOI:10.1021/acs.orglett.9b03481

Reference yield: 87.0%

: 15761-38-3
L-N-Boc-Ala

: 71400-64-1
(S)-methyl 2-amino-3-(4-(benzyloxy)-3-iodophenyl)propanoate hydrochloride

: 1364705-39-4
(S)-methyl 3-(4-(benzyloxy)-3-iodophenyl)-2-((S)-2-((tert-butoxycarbonyl)amino)propanamido)propanoate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;
DOI:10.1021/jo202105v