methyl (S)-2-[bis(tert-butoxycarbonyl) amino]-3-phenylpropanoate

Base Information

• Chemical Name: methyl (S)-2-[bis(tert-butoxycarbonyl) amino]-3-phenylpropanoate
• CAS No.: 154409-62-8
• Molecular Formula: C₂₀H₂₉NO₆
• Molecular Weight: 379.453
• Mol file: 154409-62-8.mol

Synonyms:methyl (S)-2-[bis(tert-butoxycarbonyl) amino]-3-phenylpropanoate

Chemical Property of methyl (S)-2-[bis(tert-butoxycarbonyl) amino]-3-phenylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl (S)-2-[bis(tert-butoxycarbonyl) amino]-3-phenylpropanoate

There total 5 articles about methyl (S)-2-[bis(tert-butoxycarbonyl) amino]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl (2S)-2-amino-3-phenylpropanoate (2577-90-4) → methyl (S)-2-[bis(tert-butoxycarbonyl) amino]-3-phenylpropanoate (154409-62-8)

Guidance literature:

With dmap;

DOI:10.1021/jo061159i

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + methyl (2S)-2-amino-3-phenylpropanoate hydrochloride (7524-50-7) → methyl (S)-2-[bis(tert-butoxycarbonyl) amino]-3-phenylpropanoate (154409-62-8)

Guidance literature:

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride; With sodium carbonate; In tetrahydrofuran; water; at 20 ℃; for 2h;

di-tert-butyl dicarbonate; With dmap; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1021/jo061159i

Reference yield: 92.0%

di-tert-butyl dicarbonate (24424-99-5) + (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester (51987-73-6) → methyl (S)-2-[bis(tert-butoxycarbonyl) amino]-3-phenylpropanoate (154409-62-8)

Guidance literature:

With dmap; In acetonitrile; at 22 ℃; for 16h; Inert atmosphere;

DOI:10.1002/chem.202002408

upstream raw materials:

di-tert-butyl dicarbonate

methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

methyl (2S)-2-amino-3-phenylpropanoate

(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

Downstream raw materials:

(S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester

methyl (4S,5R)-3-N-tert-butoxycarbonyl-5-phenyl-1,3-oxazolidin-2-oxo-4-carboxylate

methyl 2-(tert-butoxycarbonylamino)-3-phenylacrylate

erythro-N-(tert-butoxycarbonyl)-β-hydroxy-L-phenylalanine methyl ester